ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2017
Aspirin mono-therapy continuation does not result in more bleeding after knee arthroplasty.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- The effects of continuing aspirin and clopidogrel on perioperative outcomes in primary elective total knee and hip replacement: A systematic review and meta-analysis.Journal of orthopaedics · 2025Review
- Factors contributing to perioperative blood transfusion during total hip arthroplasty in patients continuing preoperative aspirin treatment: a nomogram prediction model.BMC musculoskeletal disorders · 2025Article
- Impact of intra- and extramedullary alignment on blood loss in total knee arthroplasty: a retrospective study.Archives of orthopaedic and trauma surgery · 2024Article
- Cemented and hybrid total hip arthroplasty lead to lower blood loss in primary total hip arthroplasty: a retrospective study.Archives of orthopaedic and trauma surgery · 2023Article
- Tranexamic acid in pertrochanteric fractures: a retrospective analysis of perioperative outcomes after fixation with a proximal femoral nail.BMC musculoskeletal disorders · 2022Article
- Preoperative Use of Aspirin in Total Knee Arthroplasty: Safe or Not?Orthopaedic surgery · 2022Article
- The Risk of Bleeding and Adverse Events with Clopidogrel in Elective Hip and Knee Arthroplasty Patients.Journal of clinical medicine · 2022Article
- [Limb ischemia after total knee arthroplasty].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019Article
- Aspirin for thromboprophylaxis in major orthopedic surgery: old drug, new tricks?Acta bio-medica : Atenei Parmensis · 2018Article
- Venous Thromboembolism Prophylaxis After TKA: Aspirin, Warfarin, Enoxaparin, or Factor Xa Inhibitors?Clinical orthopaedics and related research · 2017Article
- [Joint replacement in the elderly].Der Orthopade · 2017Review
- Preoperative haemoglobin cut-off values for the prediction of post-operative transfusion in total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCurrent clinical practice guidelines sometimes still recommend stopping aspirin five to seven days before knee arthroplasty surgery. Literature regarding multimodal blood management and continuation of anti-platelet therapy in this type of surgery is scant. The study hypothesis was that knee arthroplasty under low-dose aspirin mono-therapy continuation does not cause more total blood loss than knee arthroplasty performed without aspirin. Blood loss would be measured by haemoglobin (Hb) and haematocrit (HTC) levels drop at day 2 or day 4 for patients who benefit from multimodal bleeding control measures.
methodsA database of all patients undergoing knee arthroplasty between 2006 and 2014 was analysed. Demographic, surgical and complete blood workup data were collected. A retrospective comparison study analysed both groups in terms of blood loss, by mean calculated blood loss as haemoglobin or haematocrit drop between the preoperative Nadir value and the postoperative day 2 and 4 value. A group of 198 (44 UKA and 154 TKA) patients underwent surgery without interrupting their aspirin therapy for cardiovascular prevention. Mean (SD) age was 71 (8) and the mean (SD) BMI was 29 (5.5) kg/m
resultsThere were no differences in terms of visible (early) or hidden (late) blood loss as measured by Hb drop in between both groups. There is no difference in transfusion rates.
conclusionsModern multimodal blood management provides sufficient blood loss prevention during and after knee arthroplasty to allow physicians to continue low-dose aspirin mono-therapy for cardiovascular prevention. LEVEL OF EVIDENCE: III.
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