Evidence map›Paper›PMID 26515755›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2016

Zinc oxide nanoparticle suspensions and layer-by-layer coatings inhibit staphylococcal growth.

Matthew J McGuffie, Jin Hong, Joong Hwan Bahng, Emmanouil Glynos, Peter F Green, Nicholas A Kotov, John G Younger, J Scott VanEpps

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
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  4. Review
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  7. Article
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  9. Article
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  11. Article
  12. Frontiers in microbiology · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Implantable Device-Related Infection.Shock (Augusta, Ga.) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew J McGuffieDepartment of Emergency Medicine, Ann Arbor, MI, USA; Michigan Center for Integrative Research in Critical Care, Ann Arbor, MI, USA; Biointerfaces Institute University of Michigan, Ann Arbor, MI, USA.
Jin HongKey Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Joong Hwan BahngDepartment of Biomedical Engineering, Ann Arbor, MI, USA.
Emmanouil GlynosDepartment of Materials Science and Engineering, Ann Arbor, MI, USA; Biointerfaces Institute University of Michigan, Ann Arbor, MI, USA.
Peter F GreenDepartment of Chemical Engineering, Ann Arbor, MI, USA; Department of Materials Science and Engineering, Ann Arbor, MI, USA; Department of Applied Physics, Ann Arbor, MI, USA.
Nicholas A KotovDepartment of Chemical Engineering, Ann Arbor, MI, USA; Department of Biomedical Engineering, Ann Arbor, MI, USA; Department of Materials Science and Engineering, Ann Arbor, MI, USA; Department of Macromolecular Science and Engineering, Ann Arbor, MI, USA; Biointerfaces Institute University of Michigan, Ann Arbor, MI, USA.
John G YoungerDepartment of Emergency Medicine, Ann Arbor, MI, USA; Michigan Center for Integrative Research in Critical Care, Ann Arbor, MI, USA; Biointerfaces Institute University of Michigan, Ann Arbor, MI, USA.
J Scott VanEppsDepartment of Emergency Medicine, Ann Arbor, MI, USA; Michigan Center for Integrative Research in Critical Care, Ann Arbor, MI, USA; Biointerfaces Institute University of Michigan, Ann Arbor, MI, USA. Electronic address: jvane@med.umich.edu.

Funding

Biomechanics of Blood Stream InfectionsR01GM081702 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOLOMON, MICHAEL J · 2009 to 2017
$3.2M
NIGMS NIH HHS R01 GM081702
6 · The paper itself

Abstract

Despite a decade of engineering and process improvements, bacterial infection remains the primary threat to implanted medical devices. Zinc oxide nanoparticles (ZnO-NPs) have demonstrated antimicrobial properties. Their microbial selectivity, stability, ease of production, and low cost make them attractive alternatives to silver NPs or antimicrobial peptides. Here we sought to (1) determine the relative efficacy of ZnO-NPs on planktonic growth of medically relevant pathogens; (2) establish the role of bacterial surface chemistry on ZnO-NP effectiveness; (3) evaluate NP shape as a factor in the dose-response; and (4) evaluate layer-by-layer (LBL) ZnO-NP surface coatings on biofilm growth. ZnO-NPs inhibited bacterial growth in a shape-dependent manner not previously seen or predicted. Pyramid shaped particles were the most effective and contrary to previous work, larger particles were more effective than smaller particles. Differential susceptibility of pathogens may be related to their surface hydrophobicity. LBL ZnO-NO coatings reduced staphylococcal biofilm burden by >95%. From the Clinical Editor: The use of medical implants is widespread. However, bacterial colonization remains a major concern. In this article, the authors investigated the use of zinc oxide nanoparticles (ZnO-NPs) to prevent bacterial infection. They showed in their experiments that ZnO-NPs significantly inhibited bacterial growth. This work may present a new alternative in using ZnO-NPs in medical devices.

Indexed as

AdsorptionAnti-Bacterial AgentsBacterial AdhesionBiofilmsCell ProliferationCoated Materials, BiocompatibleMaterials TestingMetal NanoparticlesPrinting, Three-DimensionalStaphylococcusSuspensionsZinc OxideAnti-Bacterial AgentsCoated Materials, BiocompatibleSuspensionsZinc OxideBiofilmLayer-by-layerNanoparticlesStaphylococcusZinc oxide

Identifiers

PMID26515755
PMCPMC4728027

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.