ArticleNature communications2015
Allelic variation contributes to bacterial host specificity.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- One Health approach probes zoonotic non-typhoidal Salmonella infections in China: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- The truncated major pilin subunit SBP2' contributes toApplied and environmental microbiology · 2026Article
- Lineage-specific type 1 fimbriae in hypervirulent ST23 Klebsiella pneumoniae target α3β1 integrin to promote intestinal epithelial invasion.BMC microbiology · 2026Article
- Identification of OxyR as an activator of type 1 fimbriae (Microbiology spectrum · 2025Article
- A genomic and phenotypic investigation of pigeon-adaptive Salmonella.PLoS pathogens · 2025Article
- Glycan-mediated adhesion mechanisms in antibiotic-resistant bacteria.BBA advances · 2025Article
- Infection biology ofEcoSal Plus · 2024Review
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- Evaluation of the Humoral Response after Immunization with a Chimeric Subunit Vaccine against Shiga Toxin-ProducingVaccines · 2024Article
- Mechanisms of host adaptation by bacterial pathogens.FEMS microbiology reviews · 2024Review
- A Review of the Mechanisms of Bacterial Colonization of the Mammal Gut.Microorganisms · 2024Review
- The advantage of intergenic regions as genomic features for machine-learning-based host attribution ofMicrobial genomics · 2023Article
- Genome degradation promotesNational science review · 2023Article
- For Someone, You Are the Whole World: Host-Specificity ofInternational journal of molecular sciences · 2023Article
- Genomic and phenotypic characterization ofMicrobial genomics · 2023Article
- Whole-Genome Subtyping Reveals Population Structure and Host Adaptation of Salmonella Typhimurium from Wild Birds.Journal of clinical microbiology · 2023Article
- Article
- Assessing phenotypic virulence ofFrontiers in microbiology · 2023Article
- Review
- Genomic Characterization of Antimicrobial-Resistant Salmonella enterica in Duck, Chicken, and Pig Farms and Retail Markets in Eastern China.Microbiology spectrum · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
21 authors at 9 institutions in 3 countries.
Funding
Abstract
Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis of core genes within Salmonella enterica serovar Typhimurium genomes reveals a high degree of allelic variation in surface-exposed molecules, including adhesins that promote host colonization. Subsequent multinomial logistic regression, MultiPhen and Random Forest analyses of known/suspected adhesins from 580 independent Typhimurium isolates identifies distinct host-specific nsSNP signatures. Moreover, population and functional analyses of host-associated nsSNPs for FimH, the type 1 fimbrial adhesin, highlights the role of key allelic residues in host-specific adherence in vitro. Together, our data provide the first concrete evidence that functional differences between allelic variants of bacterial proteins likely contribute to pathoadaption to diverse hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.