ArticleEuropean journal of nuclear medicine and molecular imaging2016
The impact of acquisition time of planar cardiac (123)I-MIBG imaging on the late heart to mediastinum ratio.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prognostic value ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Pooled it
- Relationships between cardiac innervation/perfusion imbalance and ventricular arrhythmias: impact on invasive electrophysiological parameters and ablation procedures.European journal of nuclear medicine and molecular imaging · 2016Trial
- Optimal Protocol and Clinical Usefulness ofNuclear medicine and molecular imaging · 2023Article
- Phantom-Based Standardization Method forAnnals of nuclear cardiology · 2023Article
- Relationships between left ventricular sympathetic innervation and diastolic dysfunction: the role of myocardial innervation/perfusion mismatch.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Neuro-cardiac imaging has a proven value in patient management: Con.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Cross calibration ofAnnals of nuclear medicine · 2017Article
- Imaging the heart's brain: Simultaneous innervation/perfusion analysis in the era of new CZT cameras.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Standardization ofClinical and translational imaging · 2017Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate whether performing the late cardiac (123)I-metaiodobenzylguanidine (MIBG) scan earlier than 4 h post-injection (p.i.) has relevant impact on the late heart to mediastinum ratio (H/M ratio) in patients with heart failure (HF).
methodsForty-nine patients with HF (median left ventricular ejection fraction of 31 %, 51 % ischaemic HF) referred for cardiac (123)I-MIBG scintigraphy were scanned at 15 min (early) p.i. and at 1, 2, 3 and 4 h (late) p.i. of (123)I-MIBG. Late H/M ratios were calculated and evaluated using a linear mixed model with the mean late H/M ratio at 4 h p.i. as a reference. A difference in late H/M ratios of more than 0.10 between the different acquisition times in comparison with the late H/M ratio at 4 h p.i. was considered as clinically relevant.
resultsStatistically significant mean differences were observed between the late H/M ratios at 1, 2 and 3 h p.i. compared with the late H/M ratio at 4 h p.i. (0.09, 0.05 and 0.02, respectively). However, the mean differences did not exceed the cut-off value of 0.10. On an individual patient level, compared to the late H/M ratio at 4 h p.i., the late H/M ratios at 1, 2 and 3 h p.i. differed more than 0.10 in 24 (50 %), 9 (19 %) and 2 (4 %) patients, respectively.
conclusionVariation in acquisition time of (123)I-MIBG between 2 and 4 h p.i. does not lead to a clinically significant change in the late H/M ratio. An earlier acquisition time seems to be justified and may warrant a more time-efficient cardiac (123)I-MIBG imaging protocol.
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