Evidence map›Paper›PMID 26515626›Full record

ReviewNeurologic clinics2015

Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.

Shahram Saberi, Jennifer E Stauffer, Derek J Schulte, John Ravits

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurologic clinics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Review of the Pathology of Muscle in Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2026
    Review
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shahram SaberiDepartment of Neurosciences, ALS Translational Research, University of California (San Diego), 9500 Gilman Drive, MC0624, La Jolla, CA 92093, USA.
Jennifer E StaufferDepartment of Neurosciences, ALS Translational Research, University of California (San Diego), 9500 Gilman Drive, MC0624, La Jolla, CA 92093, USA.
Derek J SchulteDepartment of Neurosciences, ALS Translational Research, University of California (San Diego), 9500 Gilman Drive, MC0624, La Jolla, CA 92093, USA.
John RavitsDepartment of Neurosciences, ALS Translational Research, University of California (San Diego), 9500 Gilman Drive, MC0624, La Jolla, CA 92093, USA. Electronic address: jravits@ucsd.edu.

Funding

Developing ASO Therapy for Repeat Expanded C9orf72 ALS-FTDR01NS088578 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAVITS, JOHN · 2014 to 2018
$2.1M
Microgenomic Studies of ALSR21NS051738 · NINDS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI RAVITS, JOHN · 2006 to 2007
$441k
NINDS NIH HHS NS051738NINDS NIH HHS R01 NS088578
6 · The paper itself

Abstract

The neuropathologic molecular signature common to almost all sporadic amyotrophic lateral sclerosis (ALS) and most familial ALS is TDP-43 immunoreactive neuronal cytoplasmic inclusions. The neuropathologic and molecular neuropathologic features of ALS variants, primarily lateral sclerosis and progressive muscular atrophy, are less certain but also seem to share the primary features of ALS. Genetic causes, including mutations in SOD1, TDP-43, FUS, and C9orf72, all have distinctive molecular neuropathologic signatures. Neuropathology will continue to play an increasingly key role in solving the puzzle of ALS pathogenesis.

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinDNA-Binding ProteinsGenetic VariationHumansProteinsC9orf72 ProteinC9orf72 protein, humanDNA-Binding ProteinsProteinsTARDBP protein, humanAmyotrophic lateral sclerosisC9orf72Motor neuron degenerationNeuropathologyTDP-43

Identifiers

PMID26515626
PMCPMC4628785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.