Evidence map›Paper›PMID 26515549›Full record

ArticleEuropean radiology2016

Prognostic value of dipyridamole stress cardiac magnetic resonance in patients with known or suspected coronary artery disease: a mid-term follow-up study.

Gianluca Pontone, Daniele Andreini, Erika Bertella, Monica Loguercio, Marco Guglielmo, Andrea Baggiano, Giovanni Donato Aquaro, Saima Mushtaq, Sara Salerni, Paola Gripari and 11 more

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In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Prognostic value of vasodilator stress perfusion cardiovascular magnetic resonance after inconclusive stress testing.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  16. Prognostic value of perfusion cardiovascular magnetic resonance with adenosine triphosphate stress in stable coronary artery disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
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  20. (Epicardial and microvascular) angina or atypical chest pain: differential diagnoses with cardiovascular magnetic resonance.European heart journal supplements : journal of the European Society of Cardiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Gianluca PontoneCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy. gianluca.pontone@ccfm.it.
Daniele AndreiniCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Erika BertellaCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Monica LoguercioCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Marco GuglielmoCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Andrea BaggianoCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Giovanni Donato AquaroFondazione CNR/Regione Toscana "G. Monasterio", Pisa, Italy.
Saima MushtaqCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Sara SalerniInstitute of Cardiology "G. D'Annunzio", Chieti, Italy.
Paola GripariCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Carmen RossiInstitute of Cardiology "G. D'Annunzio", Chieti, Italy.
Chiara SeguriniCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Edoardo ConteCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Virginia BeltramaCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Marta GiovannardiCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Andrea Igoren GuaricciInstitute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital "Policlinico Consorziale" of Bari, Bari, Italy.
Antonio L BartorelliCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Piergiuseppe AgostoniCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Mauro PepiCentro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
Pier Giorgio MasciFondazione CNR/Regione Toscana "G. Monasterio", Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDipyridamole stress cardiac magnetic resonance (CMR) evaluates the key phases (perfusion and wall motion) of the ischemic cascade. We sought to determine the prognostic value of dipyridamole stress-CMR in consecutive patients symptomatic for chest pain.

methodsSeven hundred and ninety-three consecutive patients symptomatic for chest pain underwent dipyridamole stress-CMR and were followed up for 810 ± 665 days. Patients were classified in group 1 (no- reversible ischemia), group 2 (stress perfusion defect alone), and group 3 [stress perfusion defect plus abnormal wall motion (AWM)]. End points were "all cardiac events" (myocardial infarction, cardiac death and revascularization) and "hard cardiac events" (all cardiac events excluding revascularization).

resultsOne hundred and ninety-five (24 %) all cardiac events and 53 (7 %) hard cardiac events were observed. All and hard cardiac event rates in groups 1, 2, and 3 were 11 %, 49 %, 69 % and 4 %, 8 %, 21 %, respectively, with a higher rate in group 2 vs. group 1 (p<0.01) and group 3 vs. groups 1 and 2 (p<0.01). Multivariate analysis showed the presence of late gadolinium enhancement and stress perfusion defect plus AWM as independent predictors of all and hard cardiac events.

conclusionsDipyridamole stress-CMR improves prognostic stratification of patients through differentiation between the different components of the ischemic cascade. KEY POINTS: • Dipyridamole stress cardiac magnetic resonance helps to assess coronary artery disease. • Novel technique to study the key phases of myocardial ischemia. • Combined assessment of perfusion and motion defects. • Dipyridamole stress imaging has additional value for predicting cardiac events.

Indexed as

AgedCardiovascular DiseasesChest PainContrast MediaCoronary Artery DiseaseDipyridamoleExercise TestFemaleFollow-Up StudiesGadoliniumHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMiddle AgedMultivariate AnalysisContrast MediaDipyridamoleGadoliniumVasodilator AgentsCoronary artery diseaseMagnetic resonanceMyocardial ischemiaMyocardial perfusion imagingPrognosis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.