Evidence map›Paper›PMID 26515543›Full record

ArticleGut2017

Faecal haemoglobin concentration influences risk prediction of interval cancers resulting from inadequate colonoscopy quality: analysis of the Taiwanese Nationwide Colorectal Cancer Screening Program.

Sherry Yueh-Hsia Chiu, Shu-Ling Chuang, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Jean Ching-Yuan Fann, Dun-Cheng Chang, Yi-Chia Lee, Ming-Shiang Wu, Chu-Kuang Chou, Wen-Feng Hsu and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
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  4. Combating Post-colonoscopy Colorectal Cancer: Insight from the Trials and Cohort Studies.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Sherry Yueh-Hsia ChiuDepartment of Health Care Management, College of Management, Chang Gung University, Tao-Yuan, Taiwan.
Shu-Ling ChuangGraduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Sam Li-Sheng ChenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Amy Ming-Fang YenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Jean Ching-Yuan FannDepartment of Health Industry Management, School of Healthcare Management, Kainan University, Tao-Yuan, Taiwan.
Dun-Cheng ChangHealth Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.
Yi-Chia LeeDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chu-Kuang ChouDivision of Gastroenterology and Hepatology, Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Wen-Feng HsuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Shu-Ti ChiouHealth Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.
Han-Mo ChiuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
National Taiwan University Hospital · TWTaipei Medical University · TWChang Gung University · TWChia-Yi Christian Hospital · TWKainan University · TWMinistry of Health and Welfare · TWMinistry of Health and Welfare · KRNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInterval colorectal cancer (CRC) after colonoscopy may affect effectiveness and cost-effectiveness of screening programmes. We aimed to investigate whether and how faecal haemoglobin concentration (FHbC) of faecal immunochemical testing (FIT) affected the risk prediction of interval cancer (IC) caused by inadequate colonoscopy quality in a FIT-based population screening programme.

designFrom 2004 to 2009, 29 969 subjects underwent complete colonoscopy after positive FIT in the Taiwanese Nationwide CRC Screening Program. The IC rate was traced until the end of 2012. The incidence of IC was calculated in relation to patient characteristics, endoscopy-related factors (such adenoma detection rate (ADR)) and FHbC. Poisson regression analysis was performed to assess the potential risk factors for colonoscopy IC.

resultsOne hundred and sixty-two ICs developed after an index colonoscopy and the estimated incidence was 1.14 per 1000 person-years of observation for the entire cohort. Increased risk of IC was most remarkable in the uptake of colonoscopy in settings with ADR lower than 15% (adjusted relative risk (aRR)=3.09, 95% CI 1.55 to 6.18) and then higher FHbC (μg Hb/g faeces) (100-149: aRR=2.55, 95% CI 1.52 to 4.29, ≥150: aRR=2.74, 95% CI 1.84 to 4.09) with adjustment for older age and colorectal neoplasm detected at baseline colonoscopy. Similar findings were observed for subjects with negative index colonoscopy.

conclusionsColonoscopy ICs arising from FIT-based population screening programmes were mainly influenced by inadequate colonoscopy quality and independently predicted by FHbC that is associated with a priori chance of advanced neoplasm. This finding is helpful for future modification of screening logistics based on FHbC.

Indexed as

Early Detection of CancerOccult BloodAdenomaAgedColonoscopyColorectal NeoplasmsFecesFemaleHemoglobinsHumansImmunochemistryMaleMiddle AgedPredictive Value of TestsProgram EvaluationRisk AssessmentHemoglobinsCOLONOSCOPYCOLORECTAL CANCERCOLORECTAL CANCER SCREENINGCOLORECTAL NEOPLASIASCREENING

Identifiers

PMID26515543
PMCPMC5284478
OpenAlexW1888565459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.