ArticleDevelopmental and comparative immunology2016
Anopheles gambiae hemocytes exhibit transient states of activation.
Article in Developmental and comparative immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Multiple evolutionary routes to immune diversification across animals.International immunology · 2026Review
- Blood feeding, microbiota, and layered mosquito immunity: from pathway phenotypes to vector competence.Frontiers in immunology · 2026Review
- Characterization of Anopheles gambiae immune cells through genetic and functional immunophenotyping.Nature communications · 2025Article
- TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae.PLoS pathogens · 2025Article
- Influence of blood feeding and infection on arthropod hemocytes.Current opinion in insect science · 2025Review
- Exploring new dimensions of immune cell biology inbioRxiv : the preprint server for biology · 2024Article
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- Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes.The Journal of experimental biology · 2022Article
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- Ex vivo characterization of the circulating hemocytes of bed bugs and their responses to bacterial exposure.Journal of invertebrate pathology · 2020Article
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- Hemocyte-targeted gene expression in the female malaria mosquito using the hemolectin promoter from Drosophila.Insect biochemistry and molecular biology · 2020Article
- 20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae.mSphere · 2020Article
- Female bed bugs (Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Chemical depletion of phagocytic immune cells inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dual role of the Anopheles coluzzii Venus Kinase Receptor in both larval growth and immunity.Scientific reports · 2019Article
- Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Anopheles gambiae larvae mount stronger immune responses against bacterial infection than adults: evidence of adaptive decoupling in mosquitoes.Parasites & vectors · 2017Article
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2 authors.
Funding
Abstract
Hemocytes are crucial players of the mosquito immune system and critically affect transmission of pathogens including malaria parasites. We and others discovered previously that a blood meal is a major immune stimulus for mosquito hemocytes. To determine whether these blood meal-induced hemocyte changes in Anopheles gambiae constitute steps in cell differentiation or demonstrate transient cell activation, we analyzed the temporal pattern of these changes over the first three days post blood meal (dpbm). Flow cytometry and immunofluorescence analyses revealed a global shift of the entire hemocyte population, peaking at 1 dpbm. All hemocyte activation markers returned to pre-blood meal baseline levels within the following 24-48 h. Our observations are consistant with An. gambiae hemocytes undergoing transient activation rather than terminal differentiation upon blood feeding. Interestingly, the temporal pattern followed the gonotrophic cycle of the mosquito, strongly suggesting hormonal control of mosquito hemocyte activation and deactivation.
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