Evidence map›Paper›PMID 26515129›Full record

ArticleCellular signalling2016

Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event.

Frédéric Boal, Lorna R Hodgson, Sam E Reed, Sophie E Yarwood, Victoria J Just, David J Stephens, Mary W McCaffrey, Jeremy M Tavaré

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. GLUT4 On the move.The Biochemical journal · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Frédéric BoalSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Lorna R HodgsonSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Sam E ReedSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Sophie E YarwoodSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Victoria J JustSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
David J StephensSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Mary W McCaffreyMolecular Cell Biology Laboratory, School of Biochemistry and Cell Biology, Biosciences Institute, University College Cork, Cork, Ireland.
Jeremy M TavaréSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK. Electronic address: j.tavare@bris.ac.uk.
University of Bristol · GBUniversity College Cork · IE

Funding

Biotechnology and Biological Sciences Research Council BB/E012450/1Medical Research Council G0900177Wellcome TrustWellcome Trust 08/0003712
6 · The paper itself

Abstract

Rip11 is a Rab11 effector protein that has been shown to be important in controlling the trafficking of several intracellular cargoes, including the fatty acid transporter FAT/CD36, V-ATPase and the glucose transporter GLUT4. We have previously demonstrated that Rip11 translocates to the plasma membrane in response to insulin and here we examine the basis of this regulated phenomenon in more detail. We show that Rip11 rapidly recycles between the cell interior and surface, and that the ability of insulin to increase the appearance of Rip11 at the cell surface involves an inhibition of Rip11 internalisation from the plasma membrane. By contrast the hormone has no effect on the rate of Rip11 translocation towards the plasma membrane. The ability of insulin to inhibit Rip11 internalisation requires dynamin and class I PI3-kinases, but is independent of the activation of the protein kinase Akt; characteristics which are very similar to the mechanism by which insulin inhibits GLUT4 endocytosis.

Indexed as

AdipocytesAnimalsCarrier ProteinsCell MembraneGlucose Transporter Type 4InsulinMiceMitochondrial ProteinsPhosphatidylinositol 3-KinasesPhosphorylationProtein TransportProto-Oncogene Proteins c-aktrab GTP-Binding ProteinsCarrier ProteinsGlucose Transporter Type 4InsulinMitochondrial ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktrab GTP-Binding ProteinsRip11 protein, mouseSlc2a4 protein, mouseEndocytosisInsulinRabRecyclingRip11

Identifiers

PMID26515129
PMCPMC4678287
OpenAlexW1886465816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.