ArticleBrain, behavior, and immunity2016
Fatigue is associated with inflammation in patients with head and neck cancer before and after intensity-modulated radiation therapy.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Inflammatory Correlates and Prospective Associations of Cancer-Related Fatigue: A Systematic Review and Meta-Analysis.Psycho-oncology · 2026Pooled it
- Fatigue following head and neck cancer radiotherapy: a systematic review of dose correlates.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Biological correlates of cancer-related fatigue in older male cancer survivors.Translational psychiatry · 2026Trial
- Predicting Post-Radiotherapy Epigenetic Age Acceleration From Pre-Treatment Data Using a Machine Learning Framework in Head and Neck Cancer Patients.Cancer medicine · 2026Article
- Regimen-Related Oral Mucosal Injury: Pathobiology, Clinical Consequences and Rationale for Intervention Across Cancer Treatment Modalities.Current oncology reports · 2026Review
- Interplay between the abdominopelvic radiotherapy and gut microbiota.Frontiers in microbiology · 2025Review
- DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism.Molecular psychiatry · 2025Article
- The Skin-Brain Axis: From UV and Pigmentation to Behaviour Modulation.International journal of molecular sciences · 2024Review
- Type I interferons, inflammation, and fatigue in a longitudinal RNA study of women with breast cancer.Brain, behavior, and immunity · 2024Article
- Article
- Genes of cancer-related fatigue: a scoping review.Frontiers in oncology · 2024Article
- Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study.Journal of psychosomatic research · 2023Article
- Circulating short chain fatty acids and fatigue in patients with head and neck cancer: A longitudinal prospective study.Brain, behavior, and immunity · 2023Article
- Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer.Head & neck · 2023Observational
- The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Psychoneurological symptoms and inflammatory markers in patients with glioma in China: a network analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Associations of inflammation with neuropsychological symptom cluster in patients with Head and neck cancer: A longitudinal study.Brain, behavior, & immunity - health · 2023Article
- Article
- Anti-Inflammatory Effect of Caffeine on Muscle under Lipopolysaccharide-Induced Inflammation.Antioxidants (Basel, Switzerland) · 2023Article
- Diverse gut microbiota pattern between mild and severe cancer-related fatigue in lung cancer patients treated with first-line chemotherapy: A pilot study.Thoracic cancer · 2023Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Patients with head and neck cancer (HNC) receiving intensity-modulated radiation therapy (IMRT) have particularly high rates of fatigue, and pre- and post-radiotherapy fatigue are prognostic factors for pathologic tumor responses and poor survival. Although inflammation has been proposed as one of the potential mechanisms of fatigue in cancer patients, findings have not been consistent, and there is a dearth of longitudinal studies. Accordingly, we conducted a prospective study in 46 HNC patients pre- and one-month post-IMRT. Fatigue was measured by the Multidimensional Fatigue Inventory (MFI)-20 at both time points along with the assessment of peripheral blood inflammatory markers including interleukin (IL)-6, soluble tumor necrosis factor receptor 2, and C-reactive protein (CRP) and gene expression. Generalized estimating equations were used to examine the association between inflammatory markers and fatigue. Gene enrichment analysis using MetaCore software was performed using up-regulated genes that were significantly associated with IMRT and fatigue. Significant associations between fatigue and IL-6 as well as CRP, which were independent of time, were observed. In addition the change in fatigue from pre- to post-IMRT was positively associated with the change in IL-6 and CRP. Analysis of up-regulated gene transcripts as a function of IMRT and fatigue revealed overrepresentation of transcripts related to the defense response and nuclear factor kappa B. In conclusion, our findings support the hypotheses that inflammation is associated with fatigue over time in HNC patients. Future studies on how inflammation contributes to fatigue as well as strategies targeting inflammation to reduce fatigue are warranted.
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