Evidence map›Paper›PMID 26515030›Full record

ReviewMicrobes and infection2016

A working model for the type III secretion mechanism in Chlamydia.

Joshua C Ferrell, Kenneth A Fields

Abstract readReview
In one paragraph

Review in Microbes and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. The T3SS structural and effector genes ofFrontiers in cellular and infection microbiology · 2025
    Article
  4. Article
  5. Article
  6. Type III Secretion inMicrobiology and molecular biology reviews : MMBR · 2023
    Review
  7. Article
  8. Article
  9. TheInfection and immunity · 2022
    Article
  10. The Chlamydia trachomatis Tarp effector targets the Hippo pathway.Biochemical and biophysical research communications · 2021
    Article
  11. Article
  12. Article
  13. Murine Endometrial Organoids to ModelFrontiers in cellular and infection microbiology · 2020
    Article
  14. Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton byInternational journal of molecular sciences · 2019
    Review
  15. Article
  16. Chlamydial Infection From Outside to Inside.Frontiers in microbiology · 2019
    Review
  17. Synonymous Codon Usages as an Evolutionary Dynamic forInternational journal of molecular sciences · 2018
    Article
  18. Article
  19. Review
  20. The Loss of Expression of a Single Type 3 Effector (CT622) Strongly ReducesFrontiers in cellular and infection microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joshua C FerrellDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Kenneth A FieldsDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: Ken.fields@uky.edu.

Funding

Type III exported effectors of Chlamydia trachomatisR01AI065530 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FIELDS, KENNETH A · 2005 to 2021
$5.7M
NIAID NIH HHS AI0065530NIAID NIH HHS R01 AI065530
6 · The paper itself

Abstract

It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model herein that is based on current evidence.

Indexed as

ChlamydiaModels, BiologicalModels, MolecularType III Secretion SystemsVirulence FactorsType III Secretion SystemsVirulence FactorsEffectorPathogenesisSecretion

Identifiers

PMID26515030
PMCPMC4758891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.