ArticleEvolution; international journal of organic evolution2015
Conservative and compensatory evolution in oxidative phosphorylation complexes of angiosperms with highly divergent rates of mitochondrial genome evolution.
Article in Evolution; international journal of organic evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 83 citations in OpenAlex.
- Assembly of the complete mitochondrial genome of Ligusticum chuanxiong and its evolutionary implications.BMC genomics · 2026Article
- Introgression of thermal tolerance alleles drives adaptation despite risk of mitonuclear conflict.Molecular biology and evolution · 2026Article
- Coordinated Evolutionary Rates in Oxidative Phosphorylation Complexes of Papilionoid Legumes: Cytonuclear Coevolution and Relaxed Selection.bioRxiv : the preprint server for biology · 2026Article
- Positive and relaxed selection on mitochondrial DNA in parasitic versus predatory mites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.Molecular biology and evolution · 2025Article
- Effects of mating system and adaptedness on the evolution of fitness and mtDNA copy number in mitonuclear mismatched C. elegans.Heredity · 2025Article
- Survey ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Cytonuclear evolution in fully heterotrophic plants: lifestyles and gene function determine scenarios.BMC plant biology · 2024Article
- Nuclear compensatory evolution driven by mito-nuclear incompatibilities.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genome copy number predicts extreme evolutionary rate variation in plant mitochondrial DNA.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Chromosome-Level Genome Assembly for the Angiosperm Silene conica.Genome biology and evolution · 2023Article
- Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes.Current opinion in genetics & development · 2023Review
- Mutation pressure, drift, and the pace of molecular coevolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Aminoacyl-tRNA Synthetase Evolution within the Dynamic Tripartite Translation System of Plant Cells.Genome biology and evolution · 2023Article
- Incompatibility and Interchangeability in Molecular Evolution.Genome biology and evolution · 2023Review
- What is the potential impact of genetic divergence of plastid ribosomal genes betweenFrontiers in plant science · 2023Article
- Genomic Signatures of Mitonuclear Coevolution in Mammals.Molecular biology and evolution · 2022Article
- Article
- Inheritance through the cytoplasm.Heredity · 2022Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Interactions between nuclear and mitochondrial gene products are critical for eukaryotic cell function. Nuclear genes encoding mitochondrial-targeted proteins (N-mt genes) experience elevated rates of evolution, which has often been interpreted as evidence of nuclear compensation in response to elevated mitochondrial mutation rates. However, N-mt genes may be under relaxed functional constraints, which could also explain observed increases in their evolutionary rate. To disentangle these hypotheses, we examined patterns of sequence and structural evolution in nuclear- and mitochondrial-encoded oxidative phosphorylation proteins from species in the angiosperm genus Silene with vastly different mitochondrial mutation rates. We found correlated increases in N-mt gene evolution in species with fast-evolving mitochondrial DNA. Structural modeling revealed an overrepresentation of N-mt substitutions at positions that directly contact mutated residues in mitochondrial-encoded proteins, despite overall patterns of conservative structural evolution. These findings support the hypothesis that selection for compensatory changes in response to mitochondrial mutations contributes to the elevated rate of evolution in N-mt genes. We discuss these results in light of theories implicating mitochondrial mutation rates and mitonuclear coevolution as drivers of speciation and suggest comparative and experimental approaches that could take advantage of heterogeneity in rates of mtDNA evolution across eukaryotes to evaluate such theories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.