Evidence map›Paper›PMID 26514973›Full record

SynthesisEuropean child & adolescent psychiatry2016

Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis.

Tiantian Wang, Ling Shan, Lin Du, Junyan Feng, Zhida Xu, Wouter G Staal, Feiyong Jia

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European child & adolescent psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 5 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 138 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Tiantian WangDepartment of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
Ling ShanDepartment of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
Lin DuDepartment of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
Junyan FengDepartment of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
Zhida XuDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Wouter G StaalDepartment of Psychiatry and Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre Karakter, Centre for Child and Adolescent Psychiatry Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.
Feiyong JiaDepartment of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China. erkekangfujia@163.com.
First Hospital of Jilin University · CNJilin University · CNRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D may play an important role in the etiology of Autism Spectrum Disorders (ASD). Vitamin D is regarded as a neuroactive steroid affecting brain development and function. It plays an essential role in myelination, which is important for connectivity in the brain. Studies have shown that decreased vitamin D levels in patients, decreased maternal vitamin D levels during pregnancy, and decreased exposure to solar UVB might increase the risk for ASD. In addition, autism symptoms and global functioning may improve after vitamin D supplementation. Here, we sought to aggregate information from previous publications on vitamin D levels and ASD, in order to achieve a higher statistical power and thereby to determine the validity of vitamin D deficiency as a risk factor for ASD. For this meta-analysis, 11 studies met the inclusion and exclusion criteria, accounting for a total of 870 ASD patients and 782 healthy controls. Levels of serum 25(OH) D in participants with ASD were significantly lower than controls, suggesting that lower vitamin D level might be a risk factor for ASD.

Indexed as

AdultAutism Spectrum DisorderBrainFamilyFemaleHumansMalePregnancyRisk FactorsVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin DAutism spectrum disordersMeta-analysisReviewVitamin D

Identifiers

PMID26514973
OpenAlexW1879435919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.