Trial reportCirculation. Cardiovascular imaging2015
Right Atrial Function in Pulmonary Arterial Hypertension.
Trial report in Circulation. Cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00902174 (A 24-week Randomized Placebo-controlled, Double-blind Multi-center Clinical Trial Evaluating the Efficacy and Safety of Oral QTI571 as an add-on Therapy in the Treatment of Severe Pulmonary Arterial Hypertension), which is not on this map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 24-week Randomized Placebo-controlled, Double-blind Multi-center Clinical Trial Evaluating the Efficacy and Safety of Oral QTI571 as an add-on Therapy in the Treatment of Severe Pulmonary Arterial Hypertension: Imatinib in Pulmonary Arterial Hypertension, a Randomized, Efficacy Study (IMPRES)
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Medications for the treatment of pulmonary arterial hypertension: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Normal Ranges of Right Atrial Strain and Strain Rate by Two-Dimensional Speckle-Tracking Echocardiography: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Pooled it
- Right Ventricular Function Assessed by Speckle Tracking Echocardiography in Patients Undergoing Transcatheter Pulmonary Valve Replacement.Pediatric cardiology · 2026Article
- Echocardiographic assessment of pulmonary hypertension: a hierarchical interpretive framework for clinical decision-making and echo laboratory practice.Echo research and practice · 2026Review
- Characteristics and prognostic significance of right atrium remodeling and tricuspid regurgitation after balloon pulmonary angioplasty-application value of echocardiography.BMC cardiovascular disorders · 2026Article
- Role of imaging techniques in monitoring atrial cardiomyopathy and atrial failure: a scientific statement.ESC heart failure · 2026Review
- A fully automated explainable predictive model for diagnosing pre-capillary and post-capillary pulmonary hypertension on routine unenhanced CT: results from the ASPIRE registry.European heart journal. Digital health · 2026Article
- Transthoracic echocardiography of left ventricular underfilling improves risk stratification in pulmonary arterial hypertension.Scientific reports · 2025Article
- Prognostic value of right atrial strain in patients with chronic heart failure.BMC cardiovascular disorders · 2025Article
- Evaluation and Management of Sepsis in Pulmonary Hypertension.Journal of intensive care medicine · 2025Review
- CMR-FT right atrial strain is a novel predictive indicator in left ventricular noncompaction patients: a multi-center study.Journal of translational medicine · 2025Article
- Increased systemic venous pressure leading to intracranial hypertension in a patient with a ventriculoatrial shunt: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A Narrative Review of the Clinical Applications of Echocardiography in Right Heart Failure.Journal of clinical medicine · 2025Review
- Atrial Right-to-Left Shunting After Tetralogy of Fallot Repair Is Associated With Improved Atrial Function and Shorter Hospital Length of Stay: An Echocardiographic Cohort Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2025Article
- Right Atrial Strain in Pediatric Pulmonary Hypertension-A Prospective Observational Study.Pediatric cardiology · 2025Observational
- A Non-Invasive Approach to Pulmonary Hypertension.Journal of clinical medicine · 2025Review
- Impact of lead placement site on right ventricular function: a comparative echocardiographic analysis of apical versus septal pacing in permanent pacemaker recipients.American journal of cardiovascular disease · 2025Article
- Current Overview of the Biology and Pharmacology in Sugen/Hypoxia-Induced Pulmonary Hypertension in Rats.Journal of aerosol medicine and pulmonary drug delivery · 2024Review
- Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundElevated right atrial (RA) pressure is an established prognostic measure in pulmonary arterial hypertension (PAH). However, little is known about perturbations in RA function in PAH. METHODS AND
resultsReservoir (RA longitudinal strain [RA LS]), conduit (RA early LS rate), and active (RA late LS rate) phases were assessed by 2D speckle tracking in 65 patients with PAH, 6-minute walk distance ≤450 m, and a pulmonary vascular resistance >800 dynes·s/cm(5), despite therapy with at least 2 PAH-specific medications enrolled in the Imatinib in Pulmonary Arterial Hypertension, a Randomized Efficacy Study (IMPRES) trial and were compared with 30 healthy controls of similar age and sex. We studied the association of RA functional measures with invasive pulmonary hemodynamics, cardiac structure and function, and N-terminal pro brain natriuretic peptide. RA LS and early LS rate were reduced in PAH patients compared with controls (27.1±11.6 versus 56.9±12.7, adjusted P<0.001 and -0.6±0.5 versus -1.5±0.5, adjusted P<0.001, respectively) even after adjusting for RA area and invasive RA pressure, whereas RA late LS rate was similar between groups (-1.4±0.7 versus -1.5±0.4, P=0.42). Among PAH patients, worse RA LS correlated with greater RA size (r=-0.50, P<0.0001) and pressure (r=-0.37, P=0.002), but not pulmonary artery pressure (r=-0.07, P=0.58). Worse RA LS was also associated with right ventricular enlargement and dysfunction and higher N-terminal pro brain natriuretic peptide independent of RA size and pressure.
conclusionsRA reservoir and passive conduit functions are impaired in PAH, independent of RA size and pressure, and likely reflect right ventricular failure and overload. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00902174.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.