Evidence map›Paper›PMID 26514656›Full record

ArticleThe American journal of psychiatry2016

The Roles of Maternal Depression, Serotonin Reuptake Inhibitor Treatment, and Concomitant Benzodiazepine Use on Infant Neurobehavioral Functioning Over the First Postnatal Month.

Amy L Salisbury, Kevin E O'Grady, Cynthia L Battle, Katherine L Wisner, George M Anderson, Laura R Stroud, Cynthia L Miller-Loncar, Marion E Young, Barry M Lester

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 84 citations in OpenAlex.

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  19. Buprenorphine in Neonatal Abstinence Syndrome.Clinical pharmacology and therapeutics · 2018
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Amy L SalisburyFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Kevin E O'GradyFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Cynthia L BattleFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Katherine L WisnerFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
George M AndersonFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Laura R StroudFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Cynthia L Miller-LoncarFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Marion E YoungFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Barry M LesterFrom the Brown Center for the Study of Children at Risk, Women and Infants' Hospital, Providence, R.I.; the Department of Pediatrics and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I.; the Department of Psychology, University of Maryland, College Park, College Park, Md.; the Center for Women's Behavioral Health, Women and Infants' Hospital, Providence, R.I.; the Psychosocial Research Program, Butler Hospital, Providence, R.I.; the Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago; the Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, R.I.; and the Department of Psychology, St. Joseph's College of Maine, Standish, Maine.
Butler Hospital · USBrown University · USMiriam Hospital · US

Funding

FETAL AND NEONATAL NEUROBEHAVIOR AND PRENATAL ANTIDEPRESSANT EXPOSURE: THE CHILDR01MH078033 · NIMH · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI SALISBURY, AMY L · 2008 to 2017
$6.1M
Maternal Depression Placental HPA Regulation & Fetal-Neonatal Stress ResponseR01MH079153 · NIMH · MIRIAM HOSPITAL · PI STROUD, LAURA R · 2007 to 2011
$3.2M
Maternal Smoking: HPA and Epigenetic Pathways to Infant Neurobehavioral DeficitsR01DA031188 · NIDA · MIRIAM HOSPITAL · PI STROUD, LAURA R · 2011 to 2016
$2.8M
Treatment-Seeking for Depression Among Pregnant WomenR34MH079108 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI BATTLE, CYNTHIA L. · 2007 to 2009
$594k
Imaging the Developing Fetal Brain: Novel Markers of Risk for Maternal SmokingR03DA035896 · NIDA · MIRIAM HOSPITAL · PI STROUD, LAURA R · 2014 to 2014
$228k
Sleep and biological rhythms after fetal exposure to antidepressantsR03MH096036 · NIMH · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI SALISBURY, AMY L · 2012 to 2013
$145k
NICHD NIH HHS R01HD076223NIDA NIH HHS R01 DA031188NIDA NIH HHS R01DA031188NIDA NIH HHS R03 DA035896NIDA NIH HHS R03DA035896NIMH NIH HHS R01 MH078033NIMH NIH HHS R01MH078033NIMH NIH HHS R01 MH079153NIMH NIH HHS R01MH79153NIMH NIH HHS R03 MH096036NIMH NIH HHS R03MH096036NIMH NIH HHS R34 MH079108NIMH NIH HHS R34MH079108
6 · The paper itself

Abstract

objectiveThe purpose of this article was to systematically compare the developmental trajectory of neurobehavior over the first postnatal month for infants with prenatal exposure to pharmacologically untreated maternal depression, selective serotonin reuptake inhibitors or serotonin and norepinephrine reuptake inhibitors (collectively: SSRIs), SSRIs with concomitant benzodiazepines (SSRI plus benzodiazepine), and no maternal depression or drug treatment (no exposure).

methodWomen (N=184) were assessed at two prenatal time points to determine psychiatric diagnoses, symptom severity, and prenatal medication usage. Infants were examined with a structured neurobehavioral assessment (Neonatal Intensive Care Unit Network Neurobehavioral Scale) at multiple time points across the first postnatal month. SSRI exposure was confirmed in a subset of participants with plasma SSRI levels. General linear-mixed models were used to examine group differences in neurobehavioral scores over time with adjustment for demographic variables and depression severity.

resultsInfants in the SSRI and SSRI plus benzodiazepine groups had lower motor scores and more CNS stress signs across the first postnatal month, as well as lower self-regulation and higher arousal at day 14. Infants in the depression group had low arousal throughout the newborn period. Infants in all three clinical groups had a widening gap in scores from the no-exposure group at day 30 in their response to visual and auditory stimuli while asleep and awake. Infants in the SSRI plus benzodiazepine group had the least favorable scores on the Neonatal Intensive Care Unit Network Neurobehavioral Scale.

conclusionsNeonatal adaptation syndrome was not limited to the first 2 weeks postbirth. The profile of neurobehavioral development was different for SSRI exposure than depression alone. Concomitant benzodiazepine use may exacerbate adverse behavioral effects.

Indexed as

Child DevelopmentInfant BehaviorPrenatal Exposure Delayed EffectsAdultAnxiety DisordersArousalBenzodiazepinesCase-Control StudiesDepressive DisorderFemaleHabituation, PsychophysiologicHumansInfant, NewbornMajor Depressive DisorderMaleMuscle HypotoniaBenzodiazepinesMOVO protein, mouseSelective Serotonin Reuptake InhibitorsTranscription Factors

Identifiers

PMID26514656
PMCPMC4742381
OpenAlexW1953439392

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.