ArticleScientific reports2015
Fluorescently-tagged anti-ganglioside antibody selectively identifies peripheral nerve in living animals.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024Review
- Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging.Current opinion in chemical biology · 2023Review
- Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023Review
- Nerve spectroscopy: understanding peripheral nerve autofluorescence through photodynamics.Surgical endoscopy · 2021Article
- Turn-On Fluorescent Probe Based on a Dansyl Triarginine Peptide for Ganglioside Imaging.ACS organic & inorganic Au · 2021Article
- Review
- Intracellular G-actin targeting of peripheral sensory neurons by the multifunctional engineered protein C2C confers relief from inflammatory pain.Scientific reports · 2020Article
- Imaging in the repair of peripheral nerve injury.Nanomedicine (London, England) · 2019Article
- Nerve-targeted probes for fluorescence-guided intraoperative imaging.Theranostics · 2018Article
- Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore.Theranostics · 2017Article
- Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Antibody-based neuronal and axonal delivery vectors for targeted ligand delivery.Neural regeneration research · 2016Article
- A four-dimensional snapshot hyperspectral video-endoscope for bio-imaging applications.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Selective in vivo delivery of cargo to peripheral nervous system (PNS) has broad clinical and preclinical applications. An important applicability of this approach is systemic delivery of fluorescently conjugated ligands that selectively label PNS, which could allow visualization of peripheral nerves during any surgery. We examine the use of an anti-ganglioside monoclonal antibody (mAb) as selective neuronal delivery vector for surgical imaging of peripheral nerves. Systemic delivery of an anti-ganglioside mAb was used for selective intraneuronal/axonal delivery of fluorescent agents to visualize nerves by surgical imaging in living mice. In this study, we show that intact motor, sensory, and autonomic nerve fibers/paths are distinctly labeled following a single nanomolar systemic injection of fluorescently labeled anti-ganglioside mAb. Tissue biodistribution studies with radiolabeled mAb were used to validate neuronal uptake of fluorescently labeled mAb. Implications of this proof of concept study are that fluorescent conjugates of anti-ganglioside mAbs are valuable delivery vectors to visualize nerves during surgery to avoid nerve injury and monitor nerve degeneration and regeneration after injury. These findings support that antibodies, and their derivatives/fragments, can be used as selective neuronal delivery vector for transport of various cargos to PNS in preclinical and clinical settings.
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Registered trials
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