Evidence map›Paper›PMID 26514194›Full record

ArticleExpert review of hematology2016

Precision medicine for acute myeloid leukemia.

Catherine Lai, Judith E Karp, Christopher S Hourigan

Open access · bronzeAbstract readEditorial
In one paragraph

Article in Expert review of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. No Evidence thatDisease markers · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Elucidation of Novel Therapeutic Targets for Acute Myeloid Leukemias withInternational journal of molecular sciences · 2019
    Article
  9. Article
  10. Chronic Myeloid Leukemia with an e6a2Case reports in hematology · 2017
    Article
  11. Molecular Profiling: A Case ofCase reports in hematology · 2017
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Catherine Laia Myeloid Malignancies Section, Hematology Branch, National Heart , Lung and Blood Institute, National Institutes of Health , Bethesda , MD , USA.
Judith E Karpa Myeloid Malignancies Section, Hematology Branch, National Heart , Lung and Blood Institute, National Institutes of Health , Bethesda , MD , USA.
Christopher S Hourigana Myeloid Malignancies Section, Hematology Branch, National Heart , Lung and Blood Institute, National Institutes of Health , Bethesda , MD , USA.
National Heart Lung and Blood Institute · USJohns Hopkins University · US

Funding

Detection, prevention and treatment of acute myeloid leukemia (AML) relapse.ZIAHL006163 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI HOURIGAN, CHRISTOPHER · 2013 to 2023
$21.0M
Intramural NIH HHS ZIA HL006163
6 · The paper itself

Abstract

The goal of precision medicine is to personalize therapy based on individual patient variation, to correctly select the right treatment, for the right patient, at the right time. Acute myeloid leukemia (AML) is a heterogeneous collection of myeloid malignancies with diverse genetic etiology and the potential for intra-patient clonal evolution over time. We discuss here how the precision medicine paradigm might be applied to the care of AML patients by focusing on the potential roles of targeting therapy by patient-specific somatic mutations and aberrant pathways, ex-vivo drug sensitivity and resistance testing, high sensitivity measurements of residual disease burden and biology along with potential clinical trial and regulatory constraints.

Indexed as

Precision MedicineHumansLeukemia, Myeloid, AcutePrognosisAMLleukemiameasurable residual diseaseminimal residual diseaseMRDpersonalized medicineprecision medicinescreeningsensitivity

Identifiers

PMID26514194
PMCPMC4879871
OpenAlexW1834098917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.