ArticleCerebral cortex (New York, N.Y. : 1991)2017
A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Trial
- Subgenual anterior cingulate cortex controls sadness-induced modulations of cognitive and emotional network hubs.Scientific reports · 2018Trial
- Imbalance in excitation and inhibition in sgACC is associated with depression in dementia with Lewy bodies.Translational psychiatry · 2026Article
- Ephaptic coupling and power fluctuations in depression.bioRxiv : the preprint server for biology · 2025Article
- Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.Communications biology · 2025Article
- A computational account of joint SSRI and anti-inflammatory treatment.Frontiers in immunology · 2025Article
- Computational Modeling of the Prefrontal-Cingulate Cortex to Investigate the Role of Coupling Relationships for Balancing Emotion and Cognition.Neuroscience bulletin · 2025Article
- Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of bipolar disorder.Cognitive neurodynamics · 2024Article
- Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression.Biomedicines · 2024Article
- Manifold alteration between major depressive disorder and healthy control subjects using dynamic mode decomposition in resting-state fMRI data.Frontiers in psychiatry · 2024Article
- A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive-compulsive disorder.Cognitive neurodynamics · 2023Article
- The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion.Neuroscience and biobehavioral reviews · 2023Review
- Synapses, predictions, and prediction errors: A neocortical computational study of MDD using the temporal memory algorithm of HTM.Frontiers in psychiatry · 2023Article
- Predictive neuromodulation of cingulo-frontal neural dynamics in major depressive disorder using a brain-computer interface system: A simulation study.Frontiers in computational neuroscience · 2023Article
- Ensemble graph neural network model for classification of major depressive disorder using whole-brain functional connectivity.Frontiers in psychiatry · 2023Article
- Connectivity concepts in neuronal network modeling.PLoS computational biology · 2022Review
- It's about time: Linking dynamical systems with human neuroimaging to understand the brain.Network neuroscience (Cambridge, Mass.) · 2022Article
- Spatio-temporal graph convolutional network for diagnosis and treatment response prediction of major depressive disorder from functional connectivity.Human brain mapping · 2021Article
- Translational Informatics for Natural Products as Antidepressant Agents.Frontiers in cell and developmental biology · 2021Review
- Altered central pain processing in fibromyalgia-A multimodal neuroimaging case-control study using arterial spin labelling.PloS one · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Major depression disease (MDD) is associated with the dysfunction of multinode brain networks. However, converging evidence implicates the reciprocal interaction between midline limbic regions (typified by the ventral anterior cingulate cortex, vACC) and the dorso-lateral prefrontal cortex (dlPFC), reflecting interactions between emotions and cognition. Furthermore, growing evidence suggests a role for abnormal glutamate metabolism in the vACC, while serotonergic treatments (selective serotonin reuptake inhibitor, SSRI) effective for many patients implicate the serotonin system. Currently, no mechanistic framework describes how network dynamics, glutamate, and serotonin interact to explain MDD symptoms and treatments. Here, we built a biophysical computational model of 2 areas (vACC and dlPFC) that can switch between emotional and cognitive processing. MDD networks were simulated by slowing glutamate decay in vACC and demonstrated sustained vACC activation. This hyperactivity was not suppressed by concurrent dlPFC activation and interfered with expected dlPFC responses to cognitive signals, mimicking cognitive dysfunction seen in MDD. Simulation of clinical treatments (SSRI or deep brain stimulation) counteracted this aberrant vACC activity. Theta and beta/gamma oscillations correlated with network function, representing markers of switch-like operation in the network. The model shows how glutamate dysregulation can cause aberrant brain dynamics, respond to treatments, and be reflected in EEG rhythms as biomarkers of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.