Evidence map›Paper›PMID 26514136›Full record

ArticleSurgical endoscopy2016

Effect of bariatric surgery on systemic and adipose tissue inflammation.

Valerie G Sams, Camille Blackledge, Nadeeja Wijayatunga, Patrick Barlow, Matthew Mancini, Gregory Mancini, Naima Moustaid-Moussa

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Valerie G SamsDepartment of Surgery, University of Tennessee Medical Center, Knoxville, TN, USA. Valerie.g.sams@gmail.com.
Camille BlackledgeDepartment of Surgery, University of Tennessee Medical Center, Knoxville, TN, USA.
Nadeeja WijayatungaDepartment of Nutritional Sciences, College of Human Sciences and The Obesity Research Cluster, Texas Tech University, Lubbock, TX, USA.
Patrick BarlowDepartment of Surgery, University of Tennessee Medical Center, Knoxville, TN, USA.
Matthew ManciniDepartment of Surgery, University of Tennessee Medical Center, Knoxville, TN, USA.
Gregory ManciniDepartment of Surgery, University of Tennessee Medical Center, Knoxville, TN, USA.
Naima Moustaid-MoussaDepartment of Surgery, University of Tennessee Medical Center, Knoxville, TN, USA.
University of Tennessee Medical Center · USUniversity of Tennessee at Knoxville · USSan Antonio Military Medical Center · USTexas Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObese patients are predisposed to developing insulin resistance and associated metabolic diseases such as diabetes and cardiovascular disease. The objective of this study was to determine the effect of bariatric surgery on adipose-derived inflammatory cytokines (adipokines), which play a key role in insulin resistance and obesity. We hypothesized that there is a significant increase in serum and tissue anti-inflammatory adiponectin with a decrease in circulating pro-inflammatory TNF-α and MCP-1, leading to reduced inflammation post-bariatric surgery.

methodsIn this study, we investigated the effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic gastric band on serum and tissue levels of adiponectin and serum levels of MCP-1 and TNF-α. Samples of serum and adipose tissue were collected at the time of surgery, 2 weeks and 6 months postoperatively. Adipokine levels were assayed by ELISA kits.

resultsA significant increase in adiponectin levels 2 weeks after surgery was observed in the subcutaneous adipose tissue in both groups combined. Serum adiponectin in LRYGB patients showed an increasing trend, while MCP-1 showed a decreasing trend post-surgery. There was no difference in TNF-α among the groups. The number of patients enrolled did not allow for statistical power to be reached.

conclusionOur results show significant and rapid increases in subcutaneous adipose adiponectin as early as 2 weeks post-bariatric surgery demonstrating reduced inflammation and possibly reduced insulin resistance. Future studies are warranted in larger cohorts with additional measurements of insulin sensitivity and inflammation.

Indexed as

Gastric BypassGastroplastyAdiponectinAdultBiomarkersChemokine CCL2FemaleHumansLaparoscopyMaleSubcutaneous FatTumor Necrosis Factor-alphaAdiponectinBiomarkersCCL2 protein, humanChemokine CCL2Tumor Necrosis Factor-alphaAdipokinesBariatric surgeryInsulin resistance

Identifiers

PMID26514136
OpenAlexW1914329169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.