Evidence map›Paper›PMID 26514135›Full record

ArticleSurgical endoscopy2016

Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: results of a multicenter cohort study on 196 patients.

Mushegh A Sahakyan, Airazat M Kazaryan, Majd Rawashdeh, David Fuks, Mark Shmavonyan, Sven-Petter Haugvik, Knut Jørgen Labori, Trond Buanes, Bård Ingvald Røsok, Dejan Ignjatovic and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Development of Minimally Invasive Pancreatic Surgery: an Evidence-Based Systematic Review of Laparoscopic Versus Robotic Approaches.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
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  15. Role of surgery in pancreatic cancer.World journal of gastroenterology · 2017
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  18. Laparoscopic surgery in distal pancreatic tumors.Turkish journal of surgery · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mushegh A SahakyanThe Intervention Centre, Oslo University Hospital - Rikshospitalet, 0027, Oslo, Norway. sahakyan.mushegh@gmail.com.
Airazat M KazaryanThe Intervention Centre, Oslo University Hospital - Rikshospitalet, 0027, Oslo, Norway.
Majd RawashdehUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
David FuksDepartment of Digestive Diseases, Institut Mutualiste Montsouris, Université Paris Descartes, Paris, France.
Mark ShmavonyanThe Intervention Centre, Oslo University Hospital - Rikshospitalet, 0027, Oslo, Norway.
Sven-Petter HaugvikDepartment of Hepato-Pancreato-Billiary Sugery, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Knut Jørgen LaboriDepartment of Hepato-Pancreato-Billiary Sugery, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Trond BuanesInstitute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
Bård Ingvald RøsokDepartment of Hepato-Pancreato-Billiary Sugery, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Dejan IgnjatovicDepartment of Digestive Surgery, Akershus University Hospital, University of Oslo, Lørenskog, Norway.
Mohammad Abu HilalUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Brice GayetDepartment of Digestive Diseases, Institut Mutualiste Montsouris, Université Paris Descartes, Paris, France.
Song Cheol KimDivision of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea.
Bjørn EdwinThe Intervention Centre, Oslo University Hospital - Rikshospitalet, 0027, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaparoscopy is widely accepted as a feasible option for distal pancreatectomy. However, the experience in laparoscopic distal pancreatectomy (LDP) for pancreatic ductal adenocarcinoma (PDAC) is limited to a small number of studies, reported by expert centers. The present study aimed to evaluate perioperative and oncological outcomes after LDP for PDAC in a large, multicenter cohort of patients.

methodsA retrospective analysis of the data on 196 patients with histologically verified PDAC, operated at Oslo University Hospital-Rikshospitalet (Oslo, Norway), Asan Medical Center (Seoul, Republic of Korea), Institut Mutualiste Montsouris (Paris, France) and University Hospital Southampton (Southampton, UK) between January 2002 and April 2015 was conducted. The patients with standard (SLDP) and extended (i.e., en bloc with adjacent organ, ELDP) resections were compared in terms of perioperative and oncological outcomes.

resultsOut of 196 LDP procedures, 191 (97.4 %) were completed through laparoscopy, while five (2.6 %) were converted to open surgery. ELDP was performed in 30 (15.7 %) cases. Sixty-one (31.9 %) patients experienced postoperative complications, including 48 (25.1 %) with pancreatic fistula. The rate of clinically relevant fistula (grade B/C) was 15.7 %. Median postoperative hospital stay was 8 (2-63) days. Median follow-up was 16 months. Median survival was 31.3 months (95 % CI 22.9-39.6). Three- and 5-year actuarial survival rates were 42.4 and 30 %, respectively. SLDP was associated with significantly higher survival compared with ELDP (p = 0.032).

conclusionsLDP seems to be a feasible and safe procedure, providing satisfactory oncological outcomes in patients with PDAC.

Indexed as

LaparoscopyCarcinoma, Pancreatic DuctalCohort StudiesConversion to Open SurgeryFemaleHumansLength of StayMaleMiddle AgedPancreatectomyPancreatic NeoplasmsPostoperative ComplicationsRetrospective StudiesDuctal adenocarcinomaLaparoscopyOutcomesPancreatectomySurvival

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.