Evidence map›Paper›PMID 26514124›Full record

ArticleNutrition journal2015

Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment.

May Khattab, Christelle Abi-Rashed, Hala Ghattas, Sani Hlais, Omar Obeid

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Nutrition journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03101215 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Workload of Water Polo Players Following a Phosphorus Manipulated High Carbohydrate Meal

TypeinterventionalSponsorAmerican University of Beirut Medical CenterRan2017 to 2018Enrolled17ConditionsEnergy ExpenditureArmsphosphorus
NCT05903625 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of Lysine and Phosphorous in Double Fortified Bread on Glycemic Index (GI) of White Bread and Postprandial Glycemia

TypeinterventionalSponsorUniversity of Veterinary and Animal Sciences, Lahore - PakistanRan2023 to 2024Enrolled16ConditionsHyperglycemia, Glucose Metabolism Disorders, Metabolic Disease, Glycemic IndexArmsControl Group - Standard White Bread, Lysine Group - Lysine-Fortified Bread, Phosphorus Group - Phosphorus-Fortified Bread, Lysine and Phosphorus Group - Double Fortified Bread
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Nutrients · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Phosphate and fibroblast growth factor 23 in diabetes.Clinical science (London, England : 1979) · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. High phosphate diet suppresses lipogenesis in white adipose tissue.Journal of clinical biochemistry and nutrition · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

May KhattabDepartment of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon. mk125@aub.edu.lb.
Christelle Abi-RashedDepartment of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon. caa20@aub.edu.lb.
Hala GhattasDepartment of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon. hg15@aub.edu.lb.
Sani HlaisDepartment of Family Medicine, American University of Beirut, Beirut, Lebanon. sh95@aub.edu.lb.
Omar ObeidDepartment of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon. oo01@aub.edu.lb.
American University of Beirut · LBAmerican University of Beirut Medical Center · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFasting serum phosphorus (P) was reported to be inversely related to serum glucose and insulin, while the impact of P ingestion is not well documented. The effect of P intake with or before glucose ingestion on postprandial glucose and insulin statuses was investigated.

methodTwo cross over experiments using healthy male subjects were conducted. Experiment 1: Overnight fasted subjects (n = 7) randomly received: 500 mg of P tablets, glucose (75 g) solution with placebo or 500 mg of P tablets. Experiment 2: Overnight fasted subjects (n = 8) underwent similar procedures to those of experiment 1, except that placebo or 500 mg P tablets were given 60 min prior to glucose ingestion.

resultsIn both experiments, serum P decreased following glucose ingestion. Co-ingestion of P with glucose improved, at time 60 min, postprandial glucose (P < 0.05), insulin (P < 0.05), and insulin sensitivity index (p < 0.006), while P pre-ingestion failed to exert similar effect.

conclusionThis study suggests that postprandial glucose and insulin are affected by exogenous P supply, especially when co-ingested with glucose.

Indexed as

AdultBlood GlucoseCross-Over StudiesGlucoseGlucose Tolerance TestHumansInsulinMalePhosphorusPostprandial PeriodReference ValuesYoung AdultBlood GlucoseGlucoseInsulinPhosphorus

Identifiers

PMID26514124
PMCPMC4627612
OpenAlexW1871470305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.