Evidence map›Paper›PMID 26513769›Full record

ReviewBlood transfusion = Trasfusione del sangue2015

Chagas disease and transfusion medicine: a perspective from non-endemic countries.

Andrea Angheben, Lucia Boix, Dora Buonfrate, Federico Gobbi, Zeno Bisoffi, Simonetta Pupella, Giorgio Gandini, Giuseppe Aprili

Abstract readReview
In one paragraph

Review in Blood transfusion = Trasfusione del sangue, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Phenotypic Analysis of the Anti-Molecules (Basel, Switzerland) · 2026
    Article
  3. Babesiosis and Its Significance in Transfusion Medicine from a European Point of View.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Pathogens (Basel, Switzerland) · 2025
    Review
  10. Review
  11. Transmission risk of Trypanosoma cruzi through blood donors in a third-level care hospital.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Tumor-Suppressive Cross-Linking of Anti-International journal of molecular sciences · 2024
    Article
  16. Article
  17. The Hidden Hand of Asymptomatic Infection Hinders Control of Neglected Tropical Diseases: A Modeling Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  18. Article
  19. Article
  20. Chagas Disease in Europe.Tropical medicine and infectious disease · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Andrea AnghebenCentre for Tropical Diseases, Hospital Sacro Cuore, Negrar, Italy.
Lucia BoixInfectious Diseases Unit, Internal Medicine, University Hospital of Terrassa, Barcelona, Spain.
Dora BuonfrateCentre for Tropical Diseases, Hospital Sacro Cuore, Negrar, Italy.
Federico GobbiCentre for Tropical Diseases, Hospital Sacro Cuore, Negrar, Italy.
Zeno BisoffiCentre for Tropical Diseases, Hospital Sacro Cuore, Negrar, Italy.
Simonetta PupellaItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giorgio GandiniTransfusion Medicine Unit, University Hospital of Verona, Verona, Italy.
Giuseppe ApriliSIMTI (Italian Society for Transfusion Medicine) Past President, Verona, Italy.
Ospedale Sacro Cuore Don Calabria · ITHospital Terrassa · ESSocietà Italiana di Medicina Generale · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decades, increasing international migration and travel from Latin America to Europe have favoured the emergence of tropical diseases outside their "historical" boundaries. Chagas disease, a zoonosis endemic in rural areas of Central and South America represents a clear example of this phenomenon. In the absence of the vector, one of the potential modes of transmission of Chagas disease in non-endemic regions is through blood and blood products. As most patients with Chagas disease are asymptomatic and unaware of their condition, in case of blood donation they can inadvertently represent a serious threat to the safety of the blood supply in non-endemic areas. Since the first cases of transfusion-transmitted Chagas disease were described in the last years, non-endemic countries began to develop ad hoc strategies to prevent and control the spread of the infection. United States, Spain, United Kingdom and France first recognised the need for Trypanosoma cruzi screening in at-risk blood donors. In this review, we trace an up-to-date perspective on Chagas disease, describing its peculiar features, from epidemiological, pathological, clinical and diagnostic points of view. Moreover, we describe the possible transmission of Chagas disease through blood or blood products and the current strategies for its control, focusing on non-endemic areas.

Indexed as

Blood DonorsBlood SafetyTransfusion ReactionAdultChagas DiseaseDonor SelectionEmigration and ImmigrationEnzyme-Linked Immunosorbent AssayEuropeFemaleGlobal HealthHealth Services Needs and DemandHumansInfant, NewbornLatin AmericaMalebenzonidazoleNifurtimoxNitroimidazolesTrypanocidal Agents

Identifiers

PMID26513769
PMCPMC4624528
OpenAlexW2431531238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.