ArticleHormone research in paediatrics2015
The Relationship of Metabolic Syndrome and Body Composition in Children with Premature Adrenarche: Is It Age Related?
Article in Hormone research in paediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Premature adrenarche and metabolic risk: a systematic review and meta-analysis.European journal of endocrinology · 2025Pooled it
- Bone and body composition by DXA in girls with precocious puberty, premature thelarche, and prepubertal controls.Journal of the Endocrine Society · 2026Article
- Body composition in prepubertal children with idiopathic premature adrenarche: implications for cardiometabolic health.Pediatric research · 2025Observational
- Association of size for gestational age and dehydroepiandrosterone sulfate with cardiometabolic risk in central precocious puberty girls.Frontiers in endocrinology · 2023Article
- Evaluation of Glucose Metabolism and Cardiovascular Risk Factors in Prepubertal Girls with Premature PubarcheJournal of clinical research in pediatric endocrinology · 2022Article
- Normal and Premature Adrenarche.Endocrine reviews · 2021Review
- Update on adrenarche.Current opinion in pediatrics · 2020Review
- Cardiometabolic Risk Profile Among Young Adult Females With a History of Premature Adrenarche.Journal of the Endocrine Society · 2019Article
- Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudies that evaluate both body composition and metabolic syndrome (MeS) risk in prepubertal children with premature adrenarche (PA) are limited.
methodsFifty-eight prepubertal children (aged 5-9 years, 33 female and 25 male), 30 with PA and 28 controls, were evaluated for the presence of MeS as defined by age-modified National Cholesterol Education Program Adult Treatment Panel III criteria. A subset had dual-energy X-ray absorptiometry and bone markers (n = 23/58) to evaluate the effect of hyperandrogenism on metabolic abnormalities and body composition.
resultsThere was no difference in the prevalence of MeS between PA and controls (p = 0.138). Children with MeS were obese with an increased waist circumference (WC) and decreased high-density lipoprotein levels. Androgens were not associated with having more than one criterion for MeS (p = 0.08) but were associated with triglycerides and WC (p = 0.029 and p = 0.041, respectively). Lean mass was greater in PA subjects (p = 0.039), and androgens correlated with bone mineral density (p = 0.029) and total body fat (p = 0.008). Subjects with a higher percent of body fat were more likely to have more than one MeS risk factor (p = 0.005).
conclusionsMeS was seen only in obese subjects whether or not they had PA. Thus, it appears that obesity drives metabolic risk in the prepubertal population rather than PA. Our findings are important in determining how the prepubertal patient with PA should be evaluated for metabolic risk.
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Registered trials
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