ArticlePLoS computational biology2015
Relating Cortical Atrophy in Temporal Lobe Epilepsy with Graph Diffusion-Based Network Models.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- A Multiscale Methodology for Mapping Human Neuroanatomy.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Mode-based morphometry: A multiscale approach to mapping human neuroanatomy.Human brain mapping · 2024Article
- Altered spread of waves of activities at large scale is influenced by cortical thickness organization in temporal lobe epilepsy: a magnetic resonance imaging-high-density electroencephalography study.Brain communications · 2024Article
- Mode-based morphometry: A multiscale approach to mapping human neuroanatomy.bioRxiv : the preprint server for biology · 2023Article
- Volumetric and structural connectivity abnormalities co-localise in TLE.NeuroImage. Clinical · 2022Article
- Spectral graph theory of brain oscillations.Human brain mapping · 2020Article
- An Integrative Approach to Study Structural and Functional Network Connectivity in Epilepsy Using Imaging and Signal Data.Frontiers in integrative neuroscience · 2020Article
- Longitudinal increases in structural connectome segregation and functional connectome integration are associated with better recovery after mild TBI.Human brain mapping · 2019Article
- Neuroimaging and connectomics of drug-resistant epilepsy at multiple scales: From focal lesions to macroscale networks.Epilepsia · 2019Review
- Temporal lobe epilepsy affects spatial organization of entorhinal cortex connectivity.Epilepsy & behavior : E&B · 2018Article
- Models of Network Spread and Network Degeneration in Brain Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- Functional brain connectivity is predictable from anatomic network's Laplacian eigen-structure.NeuroImage · 2018Article
- Predicting language outcomes after stroke: Is structural disconnection a useful predictor?NeuroImage. Clinical · 2018Article
- Preserved Structural Network Organization Mediates Pathology Spread in Alzheimer's Disease Spectrum Despite Loss of White Matter Tract Integrity.Journal of Alzheimer's disease : JAD · 2018Article
- Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mesial temporal lobe epilepsy (TLE) is characterized by stereotyped origination and spread pattern of epileptogenic activity, which is reflected in stereotyped topographic distribution of neuronal atrophy on magnetic resonance imaging (MRI). Both epileptogenic activity and atrophy spread appear to follow white matter connections. We model the networked spread of activity and atrophy in TLE from first principles via two simple first order network diffusion models. Atrophy distribution is modeled as a simple consequence of the propagation of epileptogenic activity in one model, and as a progressive degenerative process in the other. We show that the network models closely reproduce the regional volumetric gray matter atrophy distribution of two epilepsy cohorts: 29 TLE subjects with medial temporal sclerosis (TLE-MTS), and 50 TLE subjects with normal appearance on MRI (TLE-no). Statistical validation at the group level suggests high correlation with measured atrophy (R = 0.586 for TLE-MTS, R = 0.283 for TLE-no). We conclude that atrophy spread model out-performs the hyperactivity spread model. These results pave the way for future clinical application of the proposed model on individual patients, including estimating future spread of atrophy, identification of seizure onset zones and surgical planning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.