Evidence map›Paper›PMID 26513397›Full record

ArticleCerebrovascular diseases (Basel, Switzerland)2015

DWI Lesion Patterns Predict Outcome in Stroke Patients with Thrombolysis.

Dezhi Liu, Fabien Scalzo, Sidney Starkman, Neal M Rao, Jason D Hinman, Doojin Kim, Latisha K Ali, Jeffrey L Saver, Ali Reza Noorian, Kwan Ng and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebrovascular diseases (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  5. Imaging evaluation of acute ischemic stroke.The Journal of international medical research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Dezhi Liu *Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Fabien Scalzo *Neurovascular Imaging Research Core, University of California Los Angeles, Los Angeles, Calif., USA.
Sidney StarkmanUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Neal M RaoUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Jason D HinmanUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Doojin KimUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Latisha K AliUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Jeffrey L SaverUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Ali Reza NoorianUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Kwan NgUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Conrad LiangUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Sunil A ShethUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Bryan YooUCLA Stroke Center, University of California Los Angeles, Los Angeles, Calif., USA.
Xinfeng LiuDepartment of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
David S LiebeskindNeurovascular Imaging Research Core, University of California Los Angeles, Los Angeles, Calif., USA.
UCLA-Jinling Neurovascular Imaging Research Collaborators
University of California, Los Angeles · USNanjing General Hospital of Nanjing Military Command · CN

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA SPOTRIAS CENTER APPLICATION RENEWAL-PROGRAM PROJECTP50NS044378 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VINTERS, HARRY V. · 2003 to 2012
$17.2M
Los Angeles - Southern California NINDS Stroke Trial Network (LASC NSTN)U10NS086497 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAVER, JEFFREY L, SUNG, GENE YONG · 2013 to 2017
$2.0M
NCRR NIH HHS M01 RR000865NINDS NIH HHS P50 NS044378NINDS NIH HHS U10 NS086497
6 · The paper itself

Abstract

backgroundLesion patterns may predict prognosis after acute ischemic stroke within the middle cerebral artery (MCA) territory; yet it remains unclear whether such imaging prognostic factors are related to patient outcome after intravenous thrombolysis.

aimsThe aim of this study is to investigate the clinical outcome after intravenous thrombolysis in acute MCA ischemic strokes with respect to diffusion-weighted imaging (DWI) lesion patterns.

methodsConsecutive acute ischemic stroke cases of the MCA territory treated over a 7-year period were retrospectively analyzed. All acute MCA stroke patients underwent a MRI scan before intravenous thrombolytic therapy was included. DWI lesions were divided into 6 patterns (territorial, other cortical, small superficial, internal border zone, small deep, and other deep infarcts). Lesion volumes were measured by dedicated imaging processing software. Favorable outcome was defined as modified Rankin scale (mRS) of 0-2 at 90 days.

resultsAmong the 172 patients included in our study, 75 (43.6%) were observed to have territorial infarct patterns or other deep infarct patterns. These patients also had higher baseline NIHSS score (p < 0.001), a higher proportion of large cerebral artery occlusions (p < 0.001) and larger infarct volume (p < 0.001). Favorable outcome (mRS 0-2) was achieved in 89 patients (51.7%). After multivariable analysis, groups with specific lesion patterns, including territorial infarct and other deep infarct pattern, were independently associated with favorable outcome (OR 0.40; 95% CI 0.16-0.99; p = 0.047).

conclusionsSpecific lesion patterns predict differential outcome after intravenous thrombolysis therapy in acute MCA stroke patients.

Indexed as

Diffusion Magnetic Resonance ImagingThrombolytic TherapyActivities of Daily LivingAgedAged, 80 and overBrain Damage, ChronicFemaleFibrinolytic AgentsFollow-Up StudiesHumansInfarction, Middle Cerebral ArteryInfusions, IntravenousMaleMiddle AgedPrognosisRecombinant ProteinsFibrinolytic AgentsRecombinant ProteinsTissue Plasminogen Activator

Identifiers

PMID26513397
PMCPMC4955553
OpenAlexW2278929099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.