ArticleSocial science & medicine (1982)2015
Neighborhood crime and depressive symptoms among African American women: Genetic moderation and epigenetic mediation of effects.
Article in Social science & medicine (1982), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis.Translational psychiatry · 2025Pooled it
- How are social determinants of health integrated into epigenetic research? A systematic review.Social science & medicine (1982) · 2021Pooled it
- Neighborhood-level deprivation measures in the United States: a scoping review and reference guide for investigators.BMC public health · 2026Article
- Article
- Biological aging and its association with serum neurofilament light chain levels in middle-aged African Americans: a prospective observational study.Aging advances · 2025Article
- Neighborhood environment associations with cognitive function and structural brain measures in older African Americans.BMC medicine · 2025Article
- Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
- Epigenetic and Coping Mechanisms of Stress in Affective Disorders: A Scoping Review.Medicina (Kaunas, Lithuania) · 2024Article
- Racial and Ethnic Residential Segregation and Monocyte DNA Methylation Age Acceleration.JAMA network open · 2023Article
- Examining the Long-term Association Between Neighborhood Socioeconomic Status and Obesity and Obesity-related Unhealthy Behaviors Among Children: Results From the Fragile Families and Child Wellbeing Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- Epigenomic Links Between Social Determinants of Health and Symptoms: A Scoping Review.Biological research for nursing · 2023Article
- Epigenetics of Early Cardiometabolic Disease: Mechanisms and Precision Medicine.Circulation research · 2023Review
- Neighborhood Disadvantage and Breast Cancer-Specific Survival.JAMA network open · 2023Article
- Romantic Relationship Status, Quality, and Depressive Symptoms Among Middle-Aged and Older Black Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Effect of Social Environments on Cardiovascular Disease in the United States.Journal of the American Heart Association · 2022Article
- Understanding Health Inequalities Through the Lens of Social Epigenetics.Annual review of public health · 2022Review
- Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities.Breast cancer research and treatment · 2022Article
- Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort.Journal of the American Statistical Association · 2022Article
- DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors.Frontiers in cardiovascular medicine · 2022Article
- Breast Cancer Disparities and the Impact of Geography.Surgical oncology clinics of North America · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionSocial scientists have long recognized the important role that neighborhood crime can play in stress-related disease, but very little is known about potential biosocial mechanisms that may link the experience of living in high-crime neighborhoods with depression.
objectiveThe current study introduces an integrated model that combines neighborhood, genetic, and epigenetic factors.
methodsHypotheses were tested with a sample of 99 African American women from the Family and Community Health Study (FACHS).
resultsAllele variants of the serotonin transporter gene (5-HTT) interact with neighborhood crime to predict depressive symptoms in a manner consonant with the differential susceptibility perspective. Furthermore, this association is mediated by DNA methylation of the promoter region of the serotonin transporter gene.
conclusionThe findings provide support for an integrated model in which changes in DNA methylation, resulting from neighborhood crime, can result in an increase or decrease in gene activity which, in turn, influences depressive symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.