Evidence map›Paper›PMID 26513029›Full record

ArticleJournal of health communication2015

Medication Nonadherence Before Hospitalization for Acute Cardiac Events.

Sunil Kripalani, Kathryn Goggins, Sam Nwosu, Jonathan Schildcrout, Amanda S Mixon, Candace McNaughton, Amanda M McDougald Scott, Kenneth A Wallston, Vanderbilt Inpatient Cohort Study

Abstract read
In one paragraph

Article in Journal of health communication, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Cardiovascular disease risk and secondary prevention of cardiovascular disease among patients with low health literacy.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sunil Kripalania Section of Hospital Medicine, Division of General Internal Medicine and Public Health, Department of Medicine , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Kathryn Gogginsb Center for Clinical Quality and Implementation Research , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Sam Nwosud Department of Biostatistics , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Jonathan Schildcroutd Department of Biostatistics , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Amanda S Mixona Section of Hospital Medicine, Division of General Internal Medicine and Public Health, Department of Medicine , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Candace McNaughtonf Department of Emergency Medicine , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Amanda M McDougald Scottc Center for Health Services Research , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Kenneth A Wallstonh School of Nursing , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
Vanderbilt Inpatient Cohort Study

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7M
Health Literacy, Hospital Discharge, and Cardiovascular OutcomesR01HL109388 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KRIPALANI, SUNIL · 2011 to 2015
$3.3M
A Randomized, ED-based Intervention to Improve Antihypertensive AdherenceK23HL125670 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCNAUGHTON, CANDACE · 2015 to 2017
$488k
NCATS NIH HHS 2 UL1 TR000445-06NCATS NIH HHS UL1 TR000445NHLBI NIH HHS K12 HL109019NHLBI NIH HHS K12HL109019NHLBI NIH HHS K23 HL125670NHLBI NIH HHS R01 HL109388
6 · The paper itself

Abstract

Medication nonadherence increases the risk of hospitalization and poor outcomes, particularly among patients with cardiovascular disease. The purpose of this study was to examine characteristics associated with medication nonadherence among adults hospitalized for cardiovascular disease. Patients in the Vanderbilt Inpatient Cohort Study who were admitted for acute coronary syndrome or heart failure completed validated assessments of self-reported medication adherence (the Adherence to Refills and Medications Scale), demographic characteristics, health literacy, numeracy, social support, depressive symptoms, and health competence. We modeled the independent predictors of nonadherence before hospitalization, standardizing estimated effects by each predictor's interquartile range. Among 1,967 patients studied, 70.7% indicated at least some degree of medication nonadherence leading up to their hospitalization. Adherence was significantly lower among patients with lower health literacy (0.18-point change in adherence score per interquartile range change in health literacy), lower numeracy (0.28), lower health competence (0.30), and more depressive symptoms (0.52) and those of younger age, of non-White race, of male gender, or with less social support. Medication nonadherence in the period before hospitalization is more prevalent among patients with lower health literacy, numeracy, or other intervenable psychosocial factors. Addressing these factors in a coordinated care model may reduce hospitalization rates.

Indexed as

Drug MonitoringAcute Coronary SyndromeAdultAgedAged, 80 and overAge FactorsAttitude to HealthDepressionEducational StatusHealth LiteracyHeart FailureHospitalizationHospitals, UniversityHumansMiddle AgedProspective Studies

Identifiers

PMID26513029
PMCPMC4705844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.