ArticleThe Journal of clinical endocrinology and metabolism2016
Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes.
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Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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63citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Pooled it
- Association between umbilical cord oxidative stress and early neonatal outcomes in gestational diabetes mellitus.BMC pregnancy and childbirth · 2026Article
- Integrative analysis of placental metabolic reprogramming and microbiome alterations in gestational diabetes mellitus (GDM).Acta diabetologica · 2026Review
- Article
- RNA-seq analysis of mitochondria-related genes regulated by AMPK in the human trophoblast cell line BeWo.Animal models and experimental medicine · 2025Article
- Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Maternal Obesity Alters Placental and Umbilical Cord Plasma Oxidative Stress, a Cross-Sectional Study.International journal of molecular sciences · 2024Article
- Maternal obesity and placental function: impaired maternal-fetal axis.Archives of gynecology and obstetrics · 2024Review
- Maternal or post-weaning dietary fructo-oligosaccharide supplementation reduces stillbirth rate of sows and diarrhea of weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Glucose uptake in trophoblasts of GDM mice is regulated by the AMPK-CLUT3 signaling pathway.Scientific reports · 2024Article
- Assessment of the effect of pre-conception care on preventing mother-to-child transmission of HIV in Nyeri County.The Pan African medical journal · 2024Article
- Identification of key metabolism-related genes and pathways in spontaneous preterm birth: combining bioinformatic analysis and machine learning.Frontiers in endocrinology · 2024Article
- Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds.Antioxidants (Basel, Switzerland) · 2023Review
- Modeling spatially varying compliance effects of PMEnvironmental research · 2023Article
- Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb.Metabolites · 2023Review
- Factors influencing thrombelastography in pregnancy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Dietary fiber supplementation during the last 50 days of gestation improves the farrowing performance of gilts by modulating insulin sensitivity, gut microbiota, and placental function.Journal of animal science · 2023Article
- Epigenetic Profiling in the Saliva of Obese Pregnant Women.Nutrients · 2022Observational
- AMPK Signaling Regulates Mitophagy and Mitochondrial ATP Production in Human Trophoblast Cell Line BeWo.Frontiers in bioscience (Landmark edition) · 2022Article
- Exposure to air pollutant mixture and gestational diabetes mellitus in Southern California: Results from electronic health record data of a large pregnancy cohort.Environment international · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 5 institutions in 3 countries.
J MartinoEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
S SebertEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
M T SeguraEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
L García-ValdésEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
J FloridoEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
M C PadillaEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
A MarcosEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
R RuedaEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
H J McArdleEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
H BudgeEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
M E SymondsEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
C CampoyEarly Life Research Unit (J.M., S.S., H.B., M.E.S.), Division of Child Health and Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom; EURISTIKOS Excellence Centre for Paediatric Research (J.M., M.T.S., L.G.-V., C.C.), University of Granada, 18016 Granada, Spain; Department of Obstetrics and Gynaecology (J.F., M.C.P.), University of Granada, Granada, Spain; Immunonutrition Research Group (A.M.), Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, E-28040 Madrid, Spain; Abbott Nutrition (R.R.), 18004 Granada, Spain; The Rowett Institute of Nutrition and Health (H.J.M.), University of Bucksburn, Aberdeen, AB21 9SB,United Kingdom; Institute of Health Sciences and Biocenter Oulu (S.S.), University of Oulu, 90014 Oulu, Finland.
Universidad de Granada · ESUniversity of Nottingham · GBAbbott (Spain) · ESInstituto de Ciencia y Tecnología de Alimentos y Nutrición · ESUniversity of Aberdeen · GB
Funding
Wellcome Trust
Abstract
contextMaternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.
objectiveOur objective was to examine whether raised maternal body mass index (BMI) and/or GDM contributed to a resetting of the expression of genes within the placenta that are involved in energy sensing, oxidative stress, inflammation, and metabolic pathways.
methodsPregnant women from Spain were recruited as part of the "Study of Maternal Nutrition and Genetics on the Foetal Adiposity Programming" survey at the first antenatal visit (12-20 weeks of gestation) and stratified according to prepregnancy BMI and the incidence of GDM. At delivery, placenta and cord blood were sampled and newborn anthropometry measured.
resultsObese women with GDM had higher estimated fetal weight at 34 gestational weeks and a greater risk of preterm deliveries and cesarean section. Birth weight was unaffected by BMI or GDM; however, women who were obese with normal glucose tolerance had increased placental weight and higher plasma glucose and leptin at term. Gene expression for markers of placental energy sensing and oxidative stress, were primarily affected by maternal obesity as mTOR was reduced, whereas SIRT-1 and UCP2 were both upregulated. In placenta from obese women with GDM, gene expression for AMPK was also reduced, whereas the downstream regulator of mTOR, p70S6KB1 was raised.
conclusionsPlacental gene expression is sensitive to both maternal obesity and GDM which both impact on energy sensing and could modulate the effect of either raised maternal BMI or GDM on birth weight.
Indexed as
Body WeightPregnancy OutcomeAdolescentAdultAnthropometryBirth WeightBody Mass IndexDiabetes, GestationalEnergy IntakeFemaleGene ExpressionGlucose IntoleranceHumansInfant, NewbornInflammationLongitudinal Studies
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