ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2015
Home dust microbiota is disordered in homes of low-income asthmatic children.
Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Indoor Microbiome: Sampling, Analysis and Emerging Trends.Environmental microbiology reports · 2026Pooled it
- Linking the bed dust microbiome with environmental factors and child respiratory health.Annals of human biology · 2025Article
- Environmental and structural factors associated with bacterial diversity in household dust across the Arizona-Sonora border.Scientific reports · 2024Article
- The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review.Environmental health perspectives · 2024Review
- Environmental and Structural Factors Associated with Bacterial Diversity in Household Dust Across the Arizona-Sonora Border.Research square · 2023Article
- Enrichment of human nasopharyngeal bacteriome with bacteria from dust after short-term exposure to indoor environment: a pilot study.BMC microbiology · 2023Article
- Determinants of bacterial and fungal microbiota in Finnish home dust: Impact of environmental biodiversity, pets, and occupants.Frontiers in microbiology · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.Cell reports · 2021Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- Building upon current knowledge and techniques of indoor microbiology to construct the next era of theory into microorganisms, health, and the built environment.Journal of exposure science & environmental epidemiology · 2020Review
- Metagenomic Characterization of Indoor Dust Bacterial and Fungal Microbiota in Homes of Asthma and Non-asthma Patients Using Next Generation Sequencing.Frontiers in microbiology · 2020Article
- Predicting Microbe-Disease Association by Learning Graph Representations and Rule-Based Inference on the Heterogeneous Network.Frontiers in microbiology · 2020Article
- Framing the discussion of microorganisms as a facet of social equity in human health.PLoS biology · 2019Article
- Contributions of the intestinal microbiome in lung immunity.European journal of immunology · 2018Review
- Comparison of microbiota and allergen profile in house dust from homes of allergic and non-allergic subjects- results from the GUSTO study.The World Allergy Organization journal · 2018Article
- PRWHMDA: Human Microbe-Disease Association Prediction by Random Walk on the Heterogeneous Network with PSO.International journal of biological sciences · 2018Article
- Indoor microbiota in severely moisture damaged homes and the impact of interventions.Microbiome · 2017Article
- The abundance of health-associated bacteria is altered in PAH polluted soils-Implications for health in urban areas?PloS one · 2017Article
- Breathing Better Through Bugs: Asthma and the Microbiome.The Yale journal of biology and medicine · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveExposure to microorganisms has repeatedly been found to influence development of atopic diseases, such as asthma. Innovative techniques have been developed that can comprehensively characterize microbial communities. The objective of this study was to characterize the home microbiota of asthmatic children utilizing 16S rRNA-based phylogenetic analysis by microarray.
methodsIn this cross-sectional study, DNA was extracted from home dust and bacterial 16S rRNA genes amplified. Bacterial products were hybridized to the PhyloChip Array and scanned using a GeneArray scanner (Affymetrix, Santa Clara, CA). The Adonis test was used to determine significant differences in the whole microbiome. Welch's t-test was used to determine significant abundance differences and genus-level richness differences.
resultsNineteen homes were included in the analysis (14 asthma and five no asthma). About 1741 operational taxonomic units (OTUs) were found in at least one sample. Bacterial genus richness did not differ in the homes of asthmatics and non-asthmatics (p = 0.09). The microbial profile was significantly different between the two groups (p = 0.025). All the top 12 OTUs with significant abundance differences were increased in homes of asthmatics and belonged to one of the five phyla (p = 0.001 to p = 7.2 × 10(-6)). Nearly half of significant abundance differences belonged to the phylum Cyanobacteria or Proteobacteria.
conclusionsThese results suggest that home dust has a characteristic microbiota which is disturbed in the homes of asthmatics, resulting in a particular abundance of Cyanobacteria and Proteobacteria. Further investigations are needed which utilize high-throughput technology to further clarify how home microbial exposures influence human health and disease.
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