ArticleeLife2015
Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 89 citations in OpenAlex.
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- Semi-automatic geometrical reconstruction and analysis of filopodia dynamics in 4D two-photon microscopy images.BMC bioinformatics · 2026Article
- Formation of sensory maps: New tools reveal novel insights into neural development.Current opinion in neurobiology · 2025Review
- Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster.Nature neuroscience · 2025Article
- Formation of Drosophila germ cells requires spatial patterning of phospholipids.Current biology : CB · 2025Article
- Cell adhesion and actin dynamics factors promote axonal extension and synapse formation in transplanted Drosophila photoreceptor cells.Development, growth & differentiation · 2024Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- A new view of axon growth and guidance grounded in the stochastic dynamics of actin networks.Open biology · 2023Article
- Asynchronous transcription and translation of neurotransmitter-related genes characterize the initial stages of neuronal maturation in Drosophila.PLoS biology · 2023Article
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- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
- Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions.The EMBO journal · 2022Article
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- An Explant System for Time-Lapse Imaging Studies of Olfactory Circuit Assembly in Drosophila.Journal of visualized experiments : JoVE · 2021Article
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- Neural specification, targeting, and circuit formation during visual system assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Mechanics and Thermodynamics of Tubule Formation in Biological Membranes.The Journal of membrane biology · 2021Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Filopodial dynamics are thought to control growth cone guidance, but the types and roles of growth cone dynamics underlying neural circuit assembly in a living brain are largely unknown. To address this issue, we have developed long-term, continuous, fast and high-resolution imaging of growth cone dynamics from axon growth to synapse formation in cultured Drosophila brains. Using R7 photoreceptor neurons as a model we show that >90% of the growth cone filopodia exhibit fast, stochastic dynamics that persist despite ongoing stepwise layer formation. Correspondingly, R7 growth cones stabilize early and change their final position by passive dislocation. N-Cadherin controls both fast filopodial dynamics and growth cone stabilization. Surprisingly, loss of N-Cadherin causes no primary targeting defects, but destabilizes R7 growth cones to jump between correct and incorrect layers. Hence, growth cone dynamics can influence wiring specificity without a direct role in target recognition and implement simple rules during circuit assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.