Evidence map›Paper›PMID 26512723›Full record

ArticlePloS one2015

An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein.

Aerin Yoon, Kye Sook Yi, So Young Chang, Sung Hwan Kim, Manki Song, Jung Ah Choi, Melissa Bourgeois, M Jaber Hossain, Li-Mei Chen, Ruben O Donis and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Aerin YoonDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea.
Kye Sook YiBiotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
So Young ChangInstitut Pasteur Korea, Gyeonggi-do, South Korea.
Sung Hwan KimBiotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Manki SongInternational Vaccine Institute, Seoul, South Korea.
Jung Ah ChoiInternational Vaccine Institute, Seoul, South Korea.
Melissa BourgeoisInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
M Jaber HossainInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Li-Mei ChenInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Ruben O DonisInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Hyori KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea.
Yujean LeeDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea.
Do Been HwangDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea.
Ji-Young MinInstitut Pasteur Korea, Gyeonggi-do, South Korea.
Shin Jae ChangBiotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Junho ChungDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea.
Institut Pasteur Korea · KRCenters for Disease Control and Prevention · USSeoul National University · KRInternational Vaccine Institute · KRCelltrion (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, four main mechanisms mediating inhibition of influenza infection by anti-hemagglutinin antibodies have been reported. Anti-globular-head-domain antibodies block either influenza virus receptor binding to the host cell or progeny virion release from the host cell. Anti-stem region antibodies hinder the membrane fusion process or induce antibody-dependent cytotoxicity to infected cells. In this study we identified a human monoclonal IgG1 antibody (CT302), which does not inhibit both the receptor binding and the membrane fusion process but efficiently reduced the nucleus entry of viral nucleoprotein suggesting a novel inhibition mechanism of viral infection by antibody. This antibody binds to the subtype-H3 hemagglutinin globular head domain of group-2 influenza viruses circulating throughout the population between 1997 and 2007.

Indexed as

Virus ReplicationAmino Acid SequenceAnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAntibody AffinityCell LineDisease Models, AnimalEpitope MappingEpitopesFerretsHemagglutinin Glycoproteins, Influenza VirusHumansImmunoglobulin GInfluenza A Virus, H3N2 SubtypeAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesHemagglutinin Glycoproteins, Influenza VirusImmunoglobulin GNucleoproteins

Identifiers

PMID26512723
PMCPMC4626144
OpenAlexW1899433213

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.