Evidence map›Paper›PMID 26512607›Full record

ArticleMedicine2015

Prospective Multicenter Feasibility Study of Laparoscopic Sentinel Basin Dissection for Organ Preserving Surgery in Gastric Cancer: Quality Control Study for Surgical Standardization Prior to Phase III Trial.

Young Joon Lee, Sang Ho Jeong, Hoon Hur, Sang-Uk Han, Jae Seok Min, Ji Yeong An, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong and 8 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Laparoscopic Sentinel Node Navigation Surgery for Stomach Preservation in Patients With Early Gastric Cancer: A Randomized Clinical Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Trial
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  8. Review
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  18. Assessment of diagnostic value of fluorescent lymphography-guided lymphadenectomy for gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Young Joon LeeFrom the Department of Surgery, Gyeongsang National University, Jinju (YJL, SHJ); Department of Surgery, Ajou University School of Medicine, Suwon (HH, S-UH); Department of Surgery, Dongnam Institute of Radiological and Medical Science, Busan (JSM); Department of Surgery, Yonsei University School of Medicine, Seoul (JYA, WJH); Department of Surgery, Soonchunhyang University College of Medicine, Bucheon (GSC, GAJ); Department of Surgery, Chonnam National University Hwasun Hospital, Hwasun (OJ, YKP, MRJ); Gastric Cancer Branch, National Cancer Center, Goyang (Y-WK, HMY, BWE, KWR); and Department of Surgery, National Cancer Center, Goyang, Korea (JYP).
Sang Ho Jeong
Hoon Hur
Sang-Uk Han
Jae Seok Min
Ji Yeong An
Woo Jin Hyung
Gyu Seok Cho
Gui Ae Jeong
Oh Jeong
Young Kyu Park
Mi Ran Jung
Young-Woo Kim
Hong Man Yoon
Bang Wool Eom
Ji Yeon Park
Keun Won Ryu
Sentinel Node Oriented Tailored Approach (SENORITA) Study Group
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical application of sentinel node biopsies in early gastric cancer is still controversial even though it appears promising. This study was conducted as a prerequisite quality control for surgical standardization of laparoscopic sentinel basin dissection (SBD) prior to the initiation of a phase III trial.Laparoscopic SBD was performed in patients with preoperative stage T1-2N0 and tumor size <4 cm in diameter. Intraoperative endoscopic submucosal injection of a standardized dual tracer was administered. All retrieved sentinel basin nodes (SBN) were investigated with intraoperative frozen hematoxylin and eosin (H&E) staining. A strict checklist consisting of 7 essential steps was followed during laparoscopic SBD as the quality control study for a phase III trial. Completion of all essential steps in the checklist for 10 cases was used to define a qualified institution.Seven institutions participated and 112 patients were enrolled in this study. However, 4 patients were excluded owing to screening failure. The mean number of cases required for institutional qualification was 15 cases (range, 13-20 cases). Sentinel basins (SB) were detected and dissected in 100 of the 108 patients (92.6%); the median number of SB and SBN was 2 and 7, respectively. Lymph node metastases were detected in 10 patients by postoperative permanent H&E staining and they were detected by SBD in all 10 patients. Frozen results of SBN were compatible with permanent staining reports.Laparoscopic SBD is feasible and demonstrated improved sensitivity in detecting metastatic lymph nodes compared to the previous study. A future phase III randomized trial comparing laparoscopic SBD with organ-preserving gastrectomy and laparoscopic standard gastrectomy seems promising for qualified institutions.

Indexed as

AdenocarcinomaAdultAgedClinical Trials, Phase III as TopicDigestive System Surgical ProceduresFeasibility StudiesFemaleHumansLaparoscopyMaleMiddle AgedOrgan Sparing TreatmentsProspective StudiesQuality ControlSentinel Lymph Node BiopsyStomach Neoplasms

Identifiers

PMID26512607
PMCPMC4985421
OpenAlexW2328486273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.