Observational studyMedicine2015
Dental Procedures and the Risk of Infective Endocarditis.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Risk of Infective Endocarditis Following Invasive Dental Procedures: A Systematic Review and Meta-Analysis.Public health reviews · 2024Pooled it
- Antibiotic prophylaxis before dental procedures to prevent infective endocarditis: a systematic review.Infection · 2023Pooled it
- The Impact of Using Kinesio Tape on Non-Infectious Complications after Impacted Mandibular Third Molar Surgery.International journal of environmental research and public health · 2021Trial
- Article
- Mapping Review of the Correlations Between Periodontitis, Dental Caries, and Endocarditis.Dentistry journal · 2025Review
- Infective Endocarditis at a Referral Children's Hospital During 19-Year Period: Trends and Outcomes.Pediatric cardiology · 2024Article
- Overprescription of antibiotics in Brazilian dental clinics: an evaluation of current practices.Scientific reports · 2024Article
- Article
- Oral streptococcal infective endocarditis among individuals at high risk following dental treatment: a nested case-crossover and case-control study.EClinicalMedicine · 2023Article
- Article
- Non-Surgical Therapy and Oral Microbiota Features in Peri-Implant Complications: A Brief Narrative Review.Healthcare (Basel, Switzerland) · 2023Review
- Insight into the Relationship between Oral Microbiota and the Inflammatory Bowel Disease.Microorganisms · 2022Review
- Article
- Infective endocarditis by HACEK: a review.Journal of cardiothoracic surgery · 2022Review
- Infective endocarditis following invasive dental procedures: IDEA case-crossover study.Health technology assessment (Winchester, England) · 2022Observational
- Analysis of Prosthetic Joint Infections Following Invasive Dental Procedures in England.JAMA network open · 2022Article
- Invasive dental procedures as risk factors for postoperative spinal infection and the effect of antibiotic prophylaxis.Journal of clinical periodontology · 2021Article
- Association of Tooth Scaling with Acute Myocardial Infarction and Analysis of the Corresponding Medical Expenditure: A Nationwide Population-Based Study.International journal of environmental research and public health · 2021Article
- Involvement of Tunisian General Practitioners in the Management of Patients at Risk of Infective Endocarditis: A Cross-Sectional Study.International journal of dentistry · 2021Article
- Comparative analysis of the oral microbiota between iron-deficiency anaemia (IDA) patients and healthy individuals by high-throughput sequencing.BMC oral health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis (IE) is an uncommon but potentially devastating disease. Recently published data have revealed a significant increase in the incidence of IE following the restriction on indications for antibiotic prophylaxis as recommended by the revised guidelines. This study aims to reexamine the basic assumption behind the rationale of prophylaxis that dental procedures increase the risk of IE.Using the Longitudinal Health Insurance Database of Taiwan, we retrospectively analyzed a total of 739 patients hospitalized for IE between 1999 and 2012. A case-crossover design was conducted to compare the odds of exposure to dental procedures within 3 months preceding hospitalization with that during matched control periods when no IE developed.In the unadjusted model, the odds ratio (OR) was 0.93 for tooth extraction (95% confidence interval [CI] 0.54-1.59), 1.64 for surgery (95% CI 0.61-4.42), 0.92 for dental scaling (95% CI 0.59-1.42), 1.69 for periodontal treatment (95% CI 0.88-3.21), and 1.29 for endodontic treatment (95% CI 0.72-2.31). The association between dental procedures and the risk of IE remained insignificant after adjustment for antibiotic use, indicating that dental procedures did not increase the risk of IE.Therefore, this result may argue against the conventional assumption on which the recommended prophylaxis for IE is based.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.