Evidence map›Paper›PMID 26512553›Full record

Observational studyMedicine2015

Evaluation of Lymphatic and Vascular Invasion in Relation to Clinicopathological Factors and Treatment Outcome in Oral Cavity Squamous Cell Carcinoma.

Mohamad Adel, Huang-Kai Kao, Cheng-Lung Hsu, Jung-Ju Huang, Li-Yu Lee, Yenlin Huang, Timothy Browne, Ngan-Ming Tsang, Yu-Liang Chang, Kai-Ping Chang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Clinicopathologic Predictive Factors of Extranodal Extension in Oral Squamous Cell Carcinoma - A Retrospective Analysis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Results of sole postoperative interstitial, high-dose-rate brachytherapy of T1-2 tongue tumours.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamad AdelFrom the Department of Otorhinolaryngology-Head and Neck Surgery (MA,K-PC); Department of Plastic and Reconstructive Surgery (H-KK,J-JH,TB); Division of Hematology-Oncology, Department of Internal Medicine (C-LH); Department of Pathology (L-YL,YH); Department of Radiation Oncology (N-MT); Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital (YLC); School of Medicine, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan (C-LH,N-MT,K-PC); and Division of Surgical Oncology, Al-Azhar Faculty of Medicine, Al-Azhar University Hospitals, Cairo, Egypt (MA).
Huang-Kai Kao
Cheng-Lung Hsu
Jung-Ju Huang
Li-Yu Lee
Yenlin Huang
Timothy Browne
Ngan-Ming Tsang
Yu-Liang Chang
Kai-Ping Chang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the associations between lymphatic and vascular invasion of oral cavity squamous cell carcinoma (OSCC) and clinicopathological manifestations, as well as their impact on patient outcomes after treatment.In total, 571 patients with primary OSCC who underwent surgery with or without adjuvant therapy were enrolled.Lymphatic and vascular invasion were found in 28 (5%) and 16 (3%) patients, respectively. Significant associations were found between lymphatic and vascular invasion and overall stage (P < 0.001 and P = 0.020, respectively), tumor stage (P = 0.009 and P = 0.025, respectively), nodal metastasis (both P < 0.001), extracapsular spread (both P < 0.001), perineural invasion (both P < 0.001), bone invasion (P = 0.004 and P = 0.001, respectively), depth of invasion (P < 0.001 and P = 0.001, respectively), and pathologic differentiation (P = 0.002 and P < 0.001, respectively). In the analysis of adverse events during follow-up, neither lymphatic nor vascular invasion was statistically associated with local recurrence, neck recurrence, and distant metastasis. Although lymphatic invasion exhibited significant associations with poorer overall survival (P < 0.001), disease-specific survival (P < 0.001), and disease-free survival (P = 0.01), it was not demonstrated to be an independent prognostic factor in all multivariate analyses.Although both lymphatic and vascular invasion are associated with many clinicopathological manifestations, neither affects the occurrence of locoregional recurrence and distant metastasis in patients with OSCC after treatment.

Indexed as

AdultAgedAged, 80 and overBlood VesselsCarcinoma, Squamous CellHumansLymphatic VesselsMiddle AgedMouth NeoplasmsPrognosisRetrospective StudiesTaiwanTreatment OutcomeYoung Adult

Identifiers

PMID26512553
PMCPMC4985367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.