ArticleHuman brain mapping2015
Long term motor function after neonatal stroke: Lesion localization above all.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Neuroimaging and Neurological Outcomes in Perinatal Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis.Pediatric neurology · 2024Pooled it
- Predicting Outcome After Newborn Stroke: A Lesion Network Mapping Study Leveraging Large-Scale Data.Stroke · 2026Article
- Article
- Executive functioning, ADHD symptoms and resting state functional connectivity in children with perinatal stroke.Brain imaging and behavior · 2024Article
- Brain growth until adolescence after a neonatal focal injury: sex related differences beyond lesion effect.Frontiers in neuroscience · 2024Article
- Association of Acute Infarct Topography With Development of Cerebral Palsy and Neurologic Impairment in Neonates With Stroke.Neurology · 2023Article
- SARS-CoV-2 Infection during Pregnancy Followed by Thalamic Neonatal Stroke-Case Report.Children (Basel, Switzerland) · 2023Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- The predictive value of lesion and disconnectome loads for upper limb motor impairment after stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Adverse motor outcome after paediatric ischaemic stroke: A nationwide cohort study.Paediatric and perinatal epidemiology · 2022Article
- Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies.Human brain mapping · 2022Article
- Ipsilesional volume loss of basal ganglia and thalamus is associated with poor hand function after ischemic perinatal stroke.BMC neurology · 2022Article
- Structural brain connectivity in children after neonatal stroke: A whole-brain fixel-based analysis.NeuroImage. Clinical · 2022Article
- Placental pathologic lesions associated with stroke in term neonates.Frontiers in endocrinology · 2022Article
- A connectome-based approach to assess motor outcome after neonatal arterial ischemic stroke.Annals of clinical and translational neurology · 2021Article
- Short-term outcomes after a neonatal arterial ischemic stroke.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Precise neonatal arterial ischemic stroke classification with a three-dimensional map of the arterial territories of the neonatal brain.Pediatric research · 2020Article
- Article
- Is the Blood Oxygenation Level-Dependent fMRI Response to Motor Tasks Altered in Children After Neonatal Stroke?Frontiers in human neuroscience · 2020Article
- Improvement in White Matter Tract Reconstruction with Constrained Spherical Deconvolution and Track Density Mapping in Low Angular Resolution Data: A Pediatric Study and Literature Review.Frontiers in pediatrics · 2017Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor outcome is variable following neonatal arterial ischemic stroke (NAIS). We analyzed the relationship between lesion characteristics on brain MRI and motor function in children who had suffered from NAIS. Thirty eight full term born children with unilateral NAIS were investigated at the age of seven. 3D T1- and 3D FLAIR-weighted MR images were acquired on a 3T MRI scanner. Lesion characteristics were compared between patients with and without cerebral palsy (CP) using the following approaches: lesion localization either using a category-based analysis, lesion mapping as well as voxel-based lesion-symptom mapping (VLSM). Using diffusion-weighted imaging the microstructure of the cortico-spinal tract (CST) was related to the status of CP by measuring DTI parameters. Whereas children with lesions sparing the primary motor system did not develop CP, CP was always present when extensive lesions damaged at least two brain structures involving the motor system. The VLSM approach provided a statistical map that confirmed the cortical lesions in the primary motor system and revealed that CP was highly correlated with lesions in close proximity to the CST. In children with CP, diffusion parameters indicated microstructural changes in the CST at the level of internal capsule and the centrum semiovale. White matter damage of the CST in centrum semiovale was a highly reproducible marker of CP. This is the first description of the implication of this latter region in motor impairment after NAIS. In conclusion, CP in childhood was closely linked to the location of the infarct in the motor system.
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