ArticleOptics letters2015
Implementation of a new scanning method for high-resolution fluorescence tomography using thermo-sensitive fluorescent agents.
Article in Optics letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Self-Guided Algorithm for Fast Image Reconstruction in Photo-Magnetic Imaging: Artificial Intelligence-Assisted Approach.Bioengineering (Basel, Switzerland) · 2024Article
- Fast ICCD-based temperature modulated fluorescence tomography.Applied optics · 2023Article
- Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform.Biomedical optics express · 2022Article
- Development of a preclinical CCD-based temperature modulated fluorescence tomography platform.Biomedical optics express · 2022Article
- Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging.Biomedical optics express · 2020Article
- A thermo-sensitive fluorescent agent based method for excitation light leakage rejection for fluorescence molecular tomography.Physics in medicine and biology · 2019Article
- Newly-Engineered Materials for Bio-Imaging Technology: A Focus on the Hybrid System of Ultrasound and Fluorescence.Frontiers in bioengineering and biotechnology · 2019Review
- Feasibility study of high spatial resolution multimodality fluorescence tomography in ex vivo biological tissue.Applied optics · 2017Article
- Experimental evaluation of the resolution and quantitative accuracy of temperature-modulated fluorescence tomography.Applied optics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Conventional fluorescence tomography provides images of the distribution of fluorescent agents within highly scattering media, but suffers from poor spatial resolution. Previously, we introduced a new method termed "temperature-modulated fluorescence tomography" (TM-FT) that generates fluorescence images with high spatial resolution. TM-FT first uses focused ultrasound to locate the distribution of temperature-sensitive fluorescence probes. Afterward, this a priori information is utilized to improve the performance of the inverse solver for conventional fluorescence tomography and reveal quantitatively accurate fluorophore concentration maps. However, the disadvantage of this novel method is the long data acquisition time as the ultrasound beam was scanned in a step-and-shoot mode. In this Letter, we present a new, fast scanning method that reduces the imaging time 40 fold. By continuously scanning the ultrasound beam over a 50 mm by 25 mm field-of-view, high-resolution fluorescence images are obtained in less than 29 min, which is critical for in vivo small animal imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.