Evidence map›Paper›PMID 26512358›Full record

ArticleOpen forum infectious diseases2015

Interpretation of Negative Molecular Test Results in Patients With Suspected or Confirmed Ebola Virus Disease: Report of Two Cases.

Jeffrey K Edwards, Christian Kleine, Vincent Munster, Ruggero Giuliani, Moses Massaquoi, Armand Sprecher, Daniel S Chertow

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Operational Research during the Ebola Emergency.Emerging infectious diseases · 2017
    Article
  4. Article
  5. Neurological Complications and Sequelae of Ebola Virus Disease.Current infectious disease reports · 2017
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Jeffrey K EdwardsMédecins Sans Frontières , Operational Center of Brussels , Belgium ; Department of International Health , School of Public Health, Johns Hopkins University , Baltimore , Maryland.
Christian KleineMédecins Sans Frontières , Operational Center of Brussels , Belgium ; Department of Infectious Diseases and Tropical Medicine , J.W. Goethe-University Hospital , Frankfurt , Germany.
Vincent MunsterLaboratory of Virology, National Institute of Allergy and Infectious Diseases , National Institutes of Health , Rocky Mountain Laboratories , Hamilton , Montana.
Ruggero GiulianiMédecins Sans Frontières , Operational Center of Brussels , Belgium.
Moses MassaquoiClinton Health Initiative , Monrovia , Liberia.
Armand SprecherMédecins Sans Frontières , Operational Center of Brussels , Belgium.
Daniel S ChertowMédecins Sans Frontières , Operational Center of Brussels , Belgium ; Department of Critical Care Medicine, Clinical Center , National Institutes of Health , Bethesda , Maryland.
Médecins Sans Frontières · BEGoethe University Frankfurt · DENational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USNational Public Health Institute of Liberia · LR

Funding

Virus Ecology UnitZIAAI001179 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MUNSTER, VINCENT · 2013 to 2025
$24.3M
International Research in CongoZIAAI001190 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MUNSTER, VINCENT · 2014 to 2025
$3.4M
6 · The paper itself

Abstract

Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) is the most sensitive quantitative diagnostic assay for detection of Ebola virus in multiple body fluids. Despite the strengths of this assay, we present 2 cases of Ebola virus disease (EVD) and highlight the potential for false-negative results during the early and late stages of EVD. The first case emphasizes the low negative-predictive value of qRT-PCR during incubation and the early febrile stage of EVD, and the second case emphasizes the potential for false-negative results during recovery and late neurologic complications of EVD. Careful interpretation of test results are needed to guide difficult admission and discharge decisions in suspected or confirmed EVD.

Indexed as

Ebolahemorrhagic feverLiberiaPCRWest Africa

Identifiers

PMID26512358
PMCPMC4621457
OpenAlexW2144149712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.