Evidence map›Paper›PMID 26512345›Full record

ArticleBrain plasticity (Amsterdam, Netherlands)

The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry.

G M Petzinger, D P Holschneider, B E Fisher, S McEwen, N Kintz, M Halliday, W Toy, J W Walsh, J Beeler, M W Jakowec

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain plasticity (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Therapeutic Mechanisms of Exercise in Parkinson's Disease.International journal of molecular sciences · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

G M PetzingerDepartment of Neurology, University of Southern California, Los Angeles, CA, 90033 ; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, 90033.
D P HolschneiderDepartment of Neurology, University of Southern California, Los Angeles, CA, 90033 ; Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, 90033.
B E FisherDepartment of Neurology, University of Southern California, Los Angeles, CA, 90033 ; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, 90033.
S McEwenAndrus Gerontology, University of Southern California, Los Angeles, CA, 90033, and Department of Psychiatry & Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, 90095.
N KintzDepartment of Neurology, University of Southern California, Los Angeles, CA, 90033.
M HallidayDepartment of Neurology, University of Southern California, Los Angeles, CA, 90033.
W ToyDepartment of Neurology, University of Southern California, Los Angeles, CA, 90033.
J W WalshAndrus Gerontology, University of Southern California, Los Angeles, CA, 90033, and Department of Psychiatry & Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, 90095.
J BeelerDepartment of Psychology, CUNY, New York.
M W JakowecDepartment of Neurology, University of Southern California, Los Angeles, CA, 90033 ; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, 90033.
University of Southern California · USCUNY School of Law · US

Funding

Glutamate-Dopamine Plasticity in Nigrostriatal Injury: Excerise Enhanced RecoveryR01NS044327 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAKOWEC, MICHAEL WALTER, WALSH, JOHN P · 2002 to 2010
$1.8M
Functional Adaptation of Neural Circuits After Exercise and Basal Ganglia InjuryR01HD060630 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HOLSCHNEIDER, DANIEL PHILIPP · 2010 to 2014
$1.6M
Biological Mechanisms of Enhanced Neuroplasticity in First-Episode SchizophreniaK01MH099431 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCEWEN, SARAH CHRISTINE · 2012 to 2016
$829k
NICHD NIH HHS R01 HD060630NIMH NIH HHS K01 MH099431NINDS NIH HHS R01 NS044327
6 · The paper itself

Abstract

Animal studies have been instrumental in providing evidence for exercise-induced neuroplasticity of corticostriatal circuits that are profoundly affected in Parkinson's disease. Exercise has been implicated in modulating dopamine and glutamate neurotransmission, altering synaptogenesis, and increasing cerebral blood flow. In addition, recent evidence supports that the type of exercise may have regional effects on brain circuitry, with skilled exercise differentially affecting frontal-striatal related circuits to a greater degree than pure aerobic exercise. Neuroplasticity in models of dopamine depletion will be reviewed with a focus on the influence of exercise on the dorsal lateral striatum and prefrontal related circuitry underlying motor and cognitive impairment in PD. Although clearly more research is needed to address major gaps in our knowledge, we hypothesize that the potential effects of exercise on inducing neuroplasticity in a circuit specific manner may occur through synergistic mechanisms that include the coupling of an increasing neuronal metabolic demand and increased blood flow. Elucidation of these mechanisms may provide important new targets for facilitating brain repair and modifying the course of disease in PD.

Indexed as

basal gangliacognitionglutamateprefrontal cortexsynaptic plasticity

Identifiers

PMID26512345
PMCPMC4621077
OpenAlexW2148878284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.