ArticleProceedings of the National Academy of Sciences of the United States of America2015
Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- An in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity.PLoS computational biology · 2026Article
- Laminar organization of visual responses in core and parabelt auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons.Nature communications · 2024Article
- Review
- Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex.Neuron · 2022Article
- The impact of neuron morphology on cortical network architecture.Cell reports · 2022Article
- Reliable Sensory Processing in Mouse Visual Cortex through Cooperative Interactions between Somatostatin and Parvalbumin Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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- Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons.Nature neuroscience · 2019Article
- Layer 3 Dynamically Coordinates Columnar Activity According to Spatial Context.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- 3D reconstruction and standardization of the rat facial nucleus for precise mapping of vibrissal motor networks.Neuroscience · 2018Article
- Systematic population spike delays across cortical layers within and between primary sensory areas.Scientific reports · 2017Article
- Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Comments and General Discussion on "The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution".Frontiers in neuroanatomy · 2016Article
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6 authors.
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Abstract
Cortical inhibitory interneurons (INs) are subdivided into a variety of morphologically and functionally specialized cell types. How the respective specific properties translate into mechanisms that regulate sensory-evoked responses of pyramidal neurons (PNs) remains unknown. Here, we investigated how INs located in cortical layer 1 (L1) of rat barrel cortex affect whisker-evoked responses of L2 PNs. To do so we combined in vivo electrophysiology and morphological reconstructions with computational modeling. We show that whisker-evoked membrane depolarization in L2 PNs arises from highly specialized spatiotemporal synaptic input patterns. Temporally L1 INs and L2-5 PNs provide near synchronous synaptic input. Spatially synaptic contacts from L1 INs target distal apical tuft dendrites, whereas PNs primarily innervate basal and proximal apical dendrites. Simulations of such constrained synaptic input patterns predicted that inactivation of L1 INs increases trial-to-trial variability of whisker-evoked responses in L2 PNs. The in silico predictions were confirmed in vivo by L1-specific pharmacological manipulations. We present a mechanism-consistent with the theory of distal dendritic shunting-that can regulate the robustness of sensory-evoked responses in PNs without affecting response amplitude or latency.
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