ArticleJournal of virology2016
VP24 Is a Chitin-Binding Protein Involved in White Spot Syndrome Virus Infection.
Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics.Biology · 2025Article
- The NamBio · 2025Article
- Functional Peroral Infectivity Complex of White Spot Syndrome Virus of Shrimp.Journal of virology · 2022Article
- Article
- Role of Cellular Receptors in the Innate Immune System of Crustaceans in Response to White Spot Syndrome Virus.Viruses · 2022Review
- Viral Shrimp Diseases Listed by the OIE: A Review.Viruses · 2022Review
- Feasibility Study on the Use of Fly Maggots (Life (Basel, Switzerland) · 2021Article
- G-Quadruplex Formation in a Putative Coding Region of White Spot Syndrome Virus: Structural and Thermodynamic Aspects.Chembiochem : a European journal of chemical biology · 2021Article
- The Molecular Mechanism of Hemocyte Immune Response inFrontiers in microbiology · 2021Article
- Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry.Emerging microbes & infections · 2020Article
- Crustacean Genome Exploration Reveals the Evolutionary Origin of White Spot Syndrome Virus.Journal of virology · 2019Article
- Transcriptome analysis of Macrobrachium rosenbergii intestines under the white spot syndrome virus and poly (I:C) challenges.PloS one · 2018Article
- A VP24-truncated isolate of white spot syndrome virus is inefficient in per os infection.Veterinary research · 2017Article
- Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus.Scientific reports · 2016Article
- Envelope protein VP24 from White spot syndrome virus: expression, purification and crystallization.Acta crystallographica. Section F, Structural biology communications · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOral ingestion is the major route of infection for the white spot syndrome virus (WSSV). However, the mechanism by which virus particles in the digestive tract invade host cells is unknown. In the present study, we demonstrate that WSSV virions can bind to chitin through one of the major envelope proteins (VP24). Mutagenesis analysis indicated that amino acids (aa) 186 to 200 in the C terminus of VP24 were required for chitin binding. Moreover, the P-VP24186-200 peptide derived from the VP24 chitin binding region significantly inhibited the VP24-chitin interaction and the WSSV-chitin interaction, implying that VP24 participates in WSSV binding to chitin. Oral inoculation experiments showed that P-VP24186-200 treatment reduced the number of virus particles remaining in the digestive tract during the early stage of infection and greatly hindered WSSV proliferation in shrimp. These data indicate that binding of WSSV to chitin through the viral envelope protein VP24 is essential for WSSV per os infection and provide new ideas for preventing WSSV infection in shrimp farms. IMPORTANCE: In this study, we show that WSSV can bind to chitin through the envelope protein VP24. The chitin-binding domain of VP24 maps to amino acids 186 to 200 in the C terminus. Binding of WSSV to chitin through the viral envelope protein VP24 is essential for WSSV per os infection. These findings not only extend our knowledge of WSSV infection but also provide new insights into strategies to prevent WSSV infection in shrimp farms.
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