Evidence map›Paper›PMID 26512051›Full record

ArticleBiological research for nursing2016

Sleep Fragmentation and Biomarkers in Juvenile Idiopathic Arthritis.

Teresa M Ward, Weichao Yuwen, Joachim Voss, Dirk Foell, Faekah Gohar, Sarah Ringold

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Prevalence of somatic and pain complaints and associations with sleep disturbance in adolescents with insomnia presenting to a behavioral sleep medicine clinic.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  6. Sleep Deficiency and Pediatric Chronic Pain.The Nursing clinics of North America · 2021
    Review
  7. Sleep and Pain in Pediatric Illness: A Conceptual Review.CNS neuroscience & therapeutics · 2016
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Teresa M WardDepartment of Family and Child Nursing, School of Nursing, University of Washington, Seattle, WA, USA teward@uw.edu.
Weichao YuwenSchool of Nursing, University of Washington, Seattle, WA, USA.
Joachim VossBiobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Seattle, WA, USA.
Dirk FoellPediatric Rheumatology and Immunology, University Children's Hospital, Muenster, Germany.
Faekah GoharPediatric Rheumatology and Immunology, University Children's Hospital, Muenster, Germany.
Sarah RingoldDepartment of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA.
University of Washington · USUniversity Hospital Münster · DESeattle Children's Hospital · US

Funding

Center for Research on the Management of Sleep DisturbancesP30NR011400 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN · 2009 to 2013
$2.2M
Sleep Disordered Breathing in Juvenile Idiopathic ArthritisR01NR012734 · NINR · UNIVERSITY OF WASHINGTON · PI WARD, TERESA M · 2011 to 2014
$1.5M
NINR NIH HHS NR011400NINR NIH HHS NR 012734NINR NIH HHS P30 NR011400NINR NIH HHS R01 NR012734
6 · The paper itself

Abstract

objectives(1) To compare sleep (nighttime sleep duration and sleep efficiency) and sleep fragmentation (movement and fragmentation index), as measured by actigraphy, and symptoms (pain and fatigue) in 8- to 14-year-old children with polyarticular and extended oligoarticular juvenile idiopathic arthritis (JIA) and (2) to examine the associations between sleep fragmentation (movement and fragmentation index) and the calcium-binding protein biomarkers S100A12 and myeloid-related protein (MRP8/14).

methodParticipants included 40 children with extended oligoarticular (n = 15) or polyarticular (n = 25) JIA and their parents. Serum protein samples were obtained during routine rheumatology clinic visits. Children completed the PedsQL Multidimensional Fatigue Scale and daily pain and sleep diaries and wore actigraphy monitors for 9 consecutive days. Parents completed the Children's Sleep Habits Questionnaire (CSHQ).

resultsOf the 40 children, 68% scored above the CSHQ clinical cutoff score for sleep disturbances. Mean nighttime sleep duration was 7.5 hr, and mean sleep efficiency was 85.3%. Group differences were not found for nighttime sleep duration, sleep efficiency, movement and fragmentation index, or S100A12 and MRP8/14 protein concentrations. In a stepwise regression, medications, joint count, and movement and fragmentation index explained 21% of the variance in MRP8/14 concentration.

conclusionDecreased nighttime sleep duration, poor sleep efficiency, and fragmented sleep were observed in our sample, regardless of JIA category. Sleep fragmentation was a significant predictor of MRP8/14 protein concentration. Additional research is needed to understand the interrelations among sleep fragmentation, effects of medication, and S100A12 and MRP8/14 protein biomarkers in JIA.

Indexed as

Arthritis, JuvenileATP-Binding Cassette TransportersBiomarkersChildChild, PreschoolFatigueFemaleHumansMaleS100A12 ProteinSleep Wake DisordersSurveys and QuestionnairesABCC11 protein, humanATP-Binding Cassette TransportersBiomarkersS100A12 ProteinactigraphyCSHQjuvenile idiopathic arthritisMRP8/14S100A12 proteinsS-calprotectinsleep fragmentation

Identifiers

PMID26512051
PMCPMC5942487
OpenAlexW2312150250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.