ArticleToxicologic pathology2016
Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans.
Article in Toxicologic pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
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- Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets.BMC research notes · 2023Article
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- Influence of SARS-CoV-2 on airway mucus production: A review and proposed model.Veterinary pathology · 2022Review
- Utility of CD138/syndecan-1 immunohistochemistry for localization of plasmacytes is tissue-dependent in B6 mice.BMC research notes · 2022Article
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- Inhaled COFrontiers in medicine · 2022Article
- Addition of 5% COAmerican journal of respiratory and critical care medicine · 2021Article
- Early intrahepatic duct defects in a cystic fibrosis porcine model.Physiological reports · 2021Article
- A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures.Physiological reports · 2021Article
- Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract.EBioMedicine · 2020Article
- Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract.bioRxiv : the preprint server for biology · 2020Article
- Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis.American journal of respiratory and critical care medicine · 2020Article
- Strategies for measuring airway mucus and mucins.Respiratory research · 2019Review
- Degraded neutrophil extracellular traps promote the growth of Actinobacillus pleuropneumoniae.Cell death & disease · 2019Article
- Article
- Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.Nucleic acids research · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Genetically engineered pigs are increasingly recognized as valuable models for the study of human disease. Immunohistochemical study of cellular markers of disease is an important tool for the investigation of these novel models so as to evaluate genotype and treatment differences. Even so, there remains a lack of validated markers for pig tissues that can serve as a translational link to human disease in organs such as the lung. Herein, we evaluate markers of cellular inflammation (cluster of differentiation [CD]3, CD79a, B cell lymphoma [BCL] 6, ionized calcium-binding adapter molecule [IBA]1, and myeloperoxidase) and those that may be involved with tissue remodeling (alpha-smooth muscle actin, beta-tubulin-III, lactoferrin, mucin [MUC]5AC, MUC5B, and cystic fibrosis transmembrane conductance regulator [CFTR]) for study of lung tissues. We compare the utility of these markers between pig and human lungs to validate translational relevance of each marker. Our results suggest these markers can be a useful addition in the pathological evaluation of porcine models of human disease.
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