ArticleScientific reports2015
Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis.Molecular human reproduction · 2025Review
- Formoterol alters chemokine expression and ameliorates pain behaviors after moderate spinal cord injury in female mice.The Journal of pharmacology and experimental therapeutics · 2025Article
- Inflammatory pain resolution by mouse serum-derived small extracellular vesicles.Brain, behavior, and immunity · 2025Article
- Evaluation of Pain-Associated Behavioral Changes in Monoiodoacetate-Induced Osteoarthritic Rats Using Dynamic Weight Bearing Analysis.Life (Basel, Switzerland) · 2024Article
- Inflammatory pain resolution by mouse serum-derived small extracellular vesicles.bioRxiv : the preprint server for biology · 2024Article
- Advanced Dynamic Weight Bearing as an Observer-independent Measure of Hyperacute Hypersensitivity in Mice.Canadian journal of pain = Revue canadienne de la douleur · 2023Article
- Objective and Quantitative Evaluation of Spontaneous Pain-Like Behaviors Using Dynamic Weight-Bearing System in Mouse Models of Postsurgical Pain.Journal of pain research · 2022Article
- Standardization of Antigen-Emulsion Preparations for the Induction of Autoimmune Disease Models.Frontiers in immunology · 2022Article
- A Novel Rat Model to Study Postsurgical Pain After Joint Replacement Surgery.Journal of pain research · 2022Article
- Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS).Frontiers in immunology · 2022Article
- Clinical-Like Cryotherapy in Acute Knee Arthritis Protects Neuromuscular Junctions of Quadriceps and Reduces Joint Inflammation in Mice.BioMed research international · 2022Article
- Article
- Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats.Heliyon · 2021Article
- Comparative Study of Anti-Gouty Arthritis Effects of Sam-Myo-Whan according to Extraction Solvents.Plants (Basel, Switzerland) · 2021Article
- Ninjin'yoeito Alleviates Neuropathic Pain Induced by Chronic Constriction Injury in Rats.Frontiers in nutrition · 2021Article
- Possible implications of animal models for the assessment of visceral pain.Animal models and experimental medicine · 2020Review
- Factors affecting the reliability of behavioral assessments for rodent osteoarthritis models.Laboratory animals · 2020Review
- Thirty days after anterior cruciate ligament transection is sufficient to induce signs of knee osteoarthritis in rats: pain, functional impairment, and synovial inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- A novel device to measure static hindlimb weight-bearing forces in pronograde rodents.Journal of neuroscience methods · 2019Article
- Clinical-like cryotherapy improves footprint patterns and reduces synovial inflammation in a rat model of post-traumatic knee osteoarthritis.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The assessment of articular nociception in experimental animals is a challenge because available methods are limited and subject to investigator influence. In an attempt to solve this problem, the purpose of this study was to establish the use of dynamic weight bearing (DWB) as a new device for evaluating joint nociception in an experimental model of antigen-induced arthritis (AIA) in mice. AIA was induced in Balb/c and C57BL/6 mice, and joint nociception was evaluated by DWB. Western Blotting and real-time PCR were used to determine protein and mRNA expression, respectively. DWB detected a dose- and time-dependent increase in joint nociception during AIA and was able to detect the dose-response effects of different classes of analgesics. Using DWB, it was possible to evaluate the participation of spinal glial cells (microglia and astrocytes) and cytokines (IL-1β and TNFα) for the genesis of joint nociception during AIA. In conclusion, the present results indicated that DWB is an effective, objective and predictable test to study both the pathophysiological mechanisms involved in arthritic nociception in mice and for evaluating novel analgesic drugs against arthritis.
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