Evidence map›Paper›PMID 26511739›Full record

ArticleJournal of clinical microbiology2016

Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance.

Daniela E Kirwan, Cesar Ugarte-Gil, Robert H Gilman, Luz Caviedes, Hasan Rizvi, Eduardo Ticona, Gonzalo Chavez, José Luis Cabrera, Eduardo D Matos, Carlton A Evans and 3 more

Open access · hybridAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. QuantitativeJournal of clinical microbiology · 2023
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  7. Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Daniela E KirwanDepartment of Medical Microbiology, St. George's Hospital, London, United Kingdom Infectious Diseases and Immunity, Imperial College London, London, United Kingdom dannikirwan@yahoo.com.
Cesar Ugarte-GilInfectious Diseases and Immunity, Imperial College London, London, United Kingdom Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Robert H GilmanDepartment of International Health, Johns Hopkins University, Baltimore, Maryland, USA Laboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru.
Luz CaviedesLaboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru.
Hasan RizviDepartment of Cellular Pathology, Barts Health NHS Trust, London, United Kingdom.
Eduardo TiconaInfectious Diseases and Tropical Medicine Unit, Hospital Nacional Dos de Mayo, Lima, Peru Universidad Nacional Mayor de San Marcos, Lima, Peru Universidad de San Martin de Porres, Lima, Peru.
Gonzalo ChavezInfectious Diseases and Tropical Medicine Unit, Hospital Nacional Dos de Mayo, Lima, Peru.
José Luis CabreraDepartment of Pulmonology, Hospital Daniel Alcides Carrión, Callao, Peru.
Eduardo D MatosUniversidad Nacional Mayor de San Marcos, Lima, Peru Infectious Diseases Unit, Hospital Nacional Arzobispo Loayza, Lima, Peru.
Carlton A EvansInfectious Diseases and Immunity, and Wellcome Trust Centre for Global Health Research, Imperial College London, London, United Kingdom IFHAD: Innovation for Health and Development, Universidad Peruana Cayetano Heredia, Lima, Peru.
David A J MooreLaboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Jon S FriedlandInfectious Diseases and Immunity, Imperial College London, London, United Kingdom.
Lymph Node TB Working Group, Peru
Universidad Peruana Cayetano Heredia · PENational University of San Marcos · PEBarts Health NHS Trust · GBDaniel Alcides Carrión National University · PEHospital Nacional Dos de Mayo · PEImperial College London · GBSt George's Hospital · GBWellcome Trust · GB

Funding

Medical Research Council MR/K007467/1Wellcome Trust
6 · The paper itself

Abstract

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Indexed as

AdolescentAdultAgedAged, 80 and overBacteriological TechniquesFemaleHumansMaleMicroscopyMiddle AgedSensitivity and SpecificityTime FactorsTuberculosis, Lymph NodeTuberculosis, Multidrug-ResistantYoung Adult

Identifiers

PMID26511739
PMCPMC4702711
OpenAlexW1862042745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.