Evidence map›Paper›PMID 26511629›Full record

ReviewCold Spring Harbor perspectives in biology2015

Meiotic Recombination: The Essence of Heredity.

Neil Hunter

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 520 papers.

0numbers the graph read from it
0cells of the map it votes in
520citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

520 citing papers in PubMed, 848 citations in OpenAlex.

  1. Article
  2. Controlling Meiotic Double-Strand Break Formation in Mice: A Web of Multivalent Protein-Protein Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Multifaceted and evolutionarily dynamic interactions betweenbioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Mechanisms That Govern Recombinase Fidelity Control During Eukaryotic Homologous Recombination.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Modified meiosis in the tardigradebioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Article

460 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Neil HunterHoward Hughes Medical Institute, Department of Microbiology & Molecular Genetics, Department of Molecular & Cellular Biology, Department of Cell Biology & Human Anatomy, University of California Davis, Davis, California 95616.
Howard Hughes Medical Institute · US

Funding

Joint Molecule Resolution During Meiotic RecombinationR01GM074223 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI HUNTER, NEIL · 2005 to 2025
$6.0M
Meiosis, SUMOylation and the ZIP3 Protein: Parallel Studies in Mouse and Yeast.R01GM084955 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HUNTER, NEIL · 2009 to 2012
$1.2M
Howard Hughes Medical InstituteNIGMS NIH HHS GM074223NIGMS NIH HHS GM084955NIGMS NIH HHS R01 GM074223NIGMS NIH HHS R01 GM084955
6 · The paper itself

Abstract

The study of homologous recombination has its historical roots in meiosis. In this context, recombination occurs as a programmed event that culminates in the formation of crossovers, which are essential for accurate chromosome segregation and create new combinations of parental alleles. Thus, meiotic recombination underlies both the independent assortment of parental chromosomes and genetic linkage. This review highlights the features of meiotic recombination that distinguish it from recombinational repair in somatic cells, and how the molecular processes of meiotic recombination are embedded and interdependent with the chromosome structures that characterize meiotic prophase. A more in-depth review presents our understanding of how crossover and noncrossover pathways of meiotic recombination are differentiated and regulated. The final section of this review summarizes the studies that have defined defective recombination as a leading cause of pregnancy loss and congenital disease in humans.

Indexed as

MeiosisModels, GeneticRecombination, GeneticChromosomesCrossing Over, GeneticDNADNA Breaks, Double-StrandedEndonucleasesFemaleHumansMaternal AgeReproductionDNAEndonucleases

Identifiers

PMID26511629
PMCPMC4665078
OpenAlexW1876047377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.