ArticleG3 (Bethesda, Md.)2015
Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of Novaluron Exposure on the Oviposition and Expression of Ovarian Development Related Genes in Silkworm,Insects · 2024Article
- Article
- Sex-lethal regulates back-splicing and generation of the sex-differentially expressed circular RNAs.Nucleic acids research · 2023Article
- Sex Lethal Gene Manipulates Gonadal Development of Medaka,International journal of molecular sciences · 2022Article
- Effects of Serine/Arginine Enriched Protein BmUP on the Development of Male Silkworm Reproductive Organs.Current issues in molecular biology · 2022Article
- Noncanonical function of the Sex lethal gene controls the protogyny phenotype in Drosophila melanogaster.Scientific reports · 2022Article
- Alterations of RNA-binding proteinFrontiers in molecular neuroscience · 2022Article
- Full Functional Sex Reversal Achieved Through Silencing ofFrontiers in endocrinology · 2021Article
- Chinmo prevents transformer alternative splicing to maintain male sex identity.PLoS genetics · 2018Article
- Article
- The sex of specific neurons controls female body growth in Drosophila.PLoS biology · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Somatic sexual determination and behavior in Drosophila melanogaster are under the control of a genetic cascade initiated by Sex lethal (Sxl). In the female soma, SXL RNA-binding protein regulates the splicing of transformer (tra) transcripts into a female-specific form. The RNA-binding protein TRA and its cofactor TRA2 function in concert in females, whereas SXL, TRA, and TRA2 are thought to not function in males. To better understand sex-specific regulation of gene expression, we analyzed male and female head transcriptome datasets for expression levels and splicing, quantifying sex-biased gene expression via RNA-Seq and qPCR. Our data uncouple the effects of Sxl and tra/tra2 in females in the-sex-biased alternative splicing of head transcripts from the X-linked locus found in neurons (fne), encoding a pan-neuronal RNA-binding protein of the ELAV family. We show that FNE protein levels are downregulated by Sxl in female heads, also independently of tra/tra2. We argue that this regulation may have important sexually dimorphic consequences for the regulation of nervous system development or function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.