Evidence map›Paper›PMID 26511484›Full record

ReviewClinical microbiology reviews2016

Intestinal Carriage of Carbapenemase-Producing Organisms: Current Status of Surveillance Methods.

Roberto Viau, Karen M Frank, Michael R Jacobs, Brigid Wilson, Keith Kaye, Curtis J Donskey, Federico Perez, Andrea Endimiani, Robert A Bonomo

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Rapid commercial CTX-M diagnostics: Performance, limitations and clinical impact.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  4. Molecular Insights into Carbapenem Resistance inInternational journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Evaluation of XpertDiagnostics (Basel, Switzerland) · 2025
    Article
  10. Epidemiological data on the acquisition of carbapenem-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Development and Validation of the MAST ISOPLEXInternational journal of molecular sciences · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Transmission of Carbapenem-Resistant Enterobacterales in an Overcrowded Emergency Department: Controlling the Spread to the Hospital.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Roberto ViauDivision of Infectious Diseases and HIV Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA.ORCID http://orcid.org/0000-0003-4982-4708
Karen M FrankMicrobiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID http://orcid.org/0000-0002-9970-4133
Michael R JacobsDepartment of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA.
Brigid WilsonGeriatric Research, Education and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Keith KayeDepartment of Medicine, Wayne State University and Detroit Medical Center, Detroit, Michigan, USA.
Curtis J DonskeyInfectious Diseases Section, Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Infection Control and Prevention, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Federico PerezInfectious Diseases Section, Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Andrea EndimianiInstitute for Infectious Diseases, Faculty of Medicine, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-3186-5421
Robert A BonomoDivision of Infectious Diseases and HIV Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA Infectious Diseases Section, Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Pharmacology, Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA robert.bonomo@va.gov.ORCID http://orcid.org/0000-0002-3299-894X
University Hospitals Cleveland Medical Center · USLouis Stokes Cleveland VA Medical Center · USGeriatric Research Education and Clinical Center · USNational Institutes of Health Clinical Center · USUniversity of Bern · CHWayne State University · US

Funding

Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
Environmental Surveillance for BacteriaZIACL010356 · CLC · CLINICAL CENTER · PI FRANK, KAREN · 2016 to 2021
$0k
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974Intramural NIH HHSNIAID NIH HHS R01 AI063517NIAID NIH HHS R01AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01AI072219NIAID NIH HHS R01 AI100560NIAID NIH HHS R01AI100560
6 · The paper itself

Abstract

Carbapenemases have become a significant mechanism for broad-spectrum β-lactam resistance in Enterobacteriaceae and other Gram-negative bacteria such as Pseudomonas and Acinetobacter spp. Intestinal carriage of carbapenemase-producing organisms (CPOs) is an important source of transmission. Isolation of carriers is one strategy that can be used to limit the spread of these bacteria. In this review, we critically examine the clinical performance, advantages, and disadvantages of methods available for the detection of intestinal carriage of CPOs. Culture-based methods (Centers for Disease Control and Prevention [CDC] protocols, chromogenic media, specialized agars, and double-disk synergy tests) for detecting carriage of CPOs are convenient due to their ready availability and low cost, but their limited sensitivity and long turnaround time may not always be optimal for infection control practices. Contemporary nucleic acid amplification techniques (NAATs) such as real-time PCR, hybridization assays, loop-mediated isothermal amplification (LAMP), or a combined culture and NAAT approach may provide fast results and/or added sensitivity and specificity compared with culture-based methods. Infection control practitioners and clinical microbiologists should be aware of the strengths and limitations of available methods to determine the most suitable approach for their medical facility to fit their infection control needs.

Indexed as

Epidemiological MonitoringAcinetobacterBacterial ProteinsBacteriological Techniquesbeta-LactamasesCarrier StateCross InfectionEnterobacteriaceaeGastrointestinal TractGram-Negative Bacterial InfectionsHumansMolecular Diagnostic TechniquesPseudomonasBacterial Proteinsbeta-Lactamasescarbapenemase

Identifiers

PMID26511484
PMCPMC4771221
OpenAlexW1827563865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.