ArticleNeurology2015
Increased CSF biomarkers of angiogenesis in Parkinson disease.
Open access · hybridAbstract read
In one paragraph
Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- The role and mechanisms of AMPK in neurovascular unit injury in Parkinson's disease.Frontiers in aging neuroscience · 2026Pooled it
- Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2018Pooled it
- Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.Annals of medicine · 2026Review
- Review
- Body Fluid-based Biomarkers for Cognitive Impairment in Parkinson's Disease.Annals of neurosciences · 2026Review
- Perioperative Inflammatory Cytokines in Parkinson's Disease.Biomolecules · 2026Observational
- Interconnected roles of astrocytes and the blood-brain barrier in Parkinson's disease: pathological evidence, mechanistic insights, and knowledge gaps.Frontiers in aging neuroscience · 2026Review
- Plasma Metabolomics Profiles in Prodromal and Clinical Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Bridging regional neurovascular unit heterogeneity and cognitive function: a review.Fluids and barriers of the CNS · 2025Review
- Article
- Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification.Nature communications · 2025Article
- Aerobic exercise-induced changes in fluid biomarkers in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- Longitudinal Multimodal Functional Imaging: An Essential Tool for Visualizing Pathologic Progression in Parkinson's Disease.Journal of movement disorders · 2025Article
- (Dys)regulation of the Immune System in Parkinson's Disease: Methodologies, Techniques, and Key Findings from Human Studies.Aging and disease · 2025Review
- From blood vessels to brain cells: Connecting the circulatory system and Parkinson's disease.Journal of Parkinson's disease · 2025Review
- Biomarkers of blood-brain barrier and neurovascular unit integrity in human cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Navigating the Landscape of Plasma Biomarkers in Alzheimer's Disease: Focus on Past, Present, and Future Clinical Applications.Neurology and therapy · 2024Review
- Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans.Science translational medicine · 2024Article
- Microphysiological Blood-Brain Barrier Systems for Disease Modeling and Drug Development.Advanced healthcare materials · 2024Review
- Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease.Brain : a journal of neurology · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
13 authors at 3 institutions in 2 countries.
Shorena JanelidzeFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Daniel LindqvistFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden. Daniel.Lindqvist@med.lu.se.
Veronica FrancardoFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Sara HallFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Henrik ZetterbergFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Kaj BlennowFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Charles H AdlerFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Thomas G BeachFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Geidy E SerranoFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Danielle van WestenFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Elisabet LondosFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
M Angela CenciFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
Oskar HanssonFrom the Clinical Memory Research Unit, Department of Clinical Sciences (S.J., E.L., O.H.), Lund University, Malmö; the Department of Clinical Sciences (D.L., S.H.), Division of Psychiatry (D.L.), Department of Experimental Medical Science (V.F., M.A.C.), and Clinical Sciences, Diagnostic Radiology (D.v.W.), Lund University, Lund; Psychiatry Skåne (D.L.), Lund; the Department of Neurology (S.H.) and Memory Clinic (E.L., O.H.), Skåne University Hospital, Lund; Institute of Neuroscience and Physiology (H.Z., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), London, UK; The Torsten Söderberg Professorship in Medicine at the Royal Swedish Academy of Sciences (K.B.), Stockholm, Sweden; Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B., G.E.S.), Sun City, AZ; and Imaging and Function (D.v.W.), Skåne University Health Care, Lund, Sweden.
University College London · GBBanner Sun Health Research Institute · USMayo Clinic in Arizona · US
Funding
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MNational Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8MNIA NIH HHS P30 AG019610NIA NIH HHS P30 AG19610NINDS NIH HHS U24 NS072026
Abstract
objectiveTo study biomarkers of angiogenesis in Parkinson disease (PD), and how these are associated with clinical characteristics, blood-brain barrier (BBB) permeability, and cerebrovascular disease.
methodsIn this cross-sectional analysis, 38 elderly controls and 100 patients with PD (82 without dementia and 18 with dementia) were included from the prospective Swedish BioFinder study. CSF samples were analyzed for the angiogenesis biomarkers vascular endothelial growth factor (VEGF); its receptors, VEGFR-1 and VEGFR-2; placental growth factor (PlGF); angiopoietin 2 (Ang2); and interleukin-8. BBB permeability, white matter lesions (WMLs), and cerebral microbleeds (CMB) were assessed. CSF angiogenesis biomarkers were also measured in 2 validation cohorts: (1) 64 controls and 87 patients with PD with dementia; and (2) 35 controls and 93 patients with neuropathologically confirmed diagnosis of PD with and without dementia.
resultsPatients with PD without dementia displayed higher CSF levels of VEGF, PlGF, and sVEGFR-2, and lower levels of Ang2, compared to controls. Similar alterations in VEGF, PlGF, and Ang2 levels were observed in patients with PD with dementia. Angiogenesis markers were associated with gait difficulties and orthostatic hypotension as well as with more pronounced BBB permeability, WMLs, and CMB. Moreover, higher levels of VEGF and PlGF levels were associated with increased CSF levels of neurofilament light (a marker of neurodegeneration) and monocyte chemotactic protein-1 (a marker of glial activation). The main results were validated in the 2 additional cohorts.
conclusionsCSF biomarkers of angiogenesis are increased in PD, and they are associated with gait difficulties, BBB dysfunction, WMLs, and CMB. Abnormal angiogenesis may be important in PD pathogenesis and contribute to dopa-resistant symptoms.
Indexed as
AgedAngiogenesis Inducing AgentsBiomarkersCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedNeovascularization, PathologicParkinson DiseaseProspective StudiesReproducibility of ResultsAngiogenesis Inducing AgentsBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.