ArticleNeurology2015
Risk of rupture of unruptured cerebral aneurysms in elderly patients.
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Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22citing papers in PubMed, 1 pooled it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Risk factors for the rupture of intracranial aneurysms: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Intracranial aneurysms as a manifestation of premature vascular aging: Cellular senescence, inflammaging, and wall degeneration.Ageing research reviews · 2026Review
- Frailty and Severe White Matter Lesions Are Risk Factors for Surgical Treatment for Unruptured Cerebral Aneurysm in Older Adults.Neurologia medico-chirurgica · 2026Article
- Morphological characteristics of brain aneurysms among age groups.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Observation versus coiling for unruptured intracranial aneurysms in octogenarians: A decision-analytic modeling study.PloS one · 2026Article
- Effectiveness and safety of the Sugita clip for ruptured and unruptured intracranial aneurysms: A retrospective cohort study.Surgical neurology international · 2026Article
- Chronological and Biological Age in Predicting Outcomes of Older Patients in Neurosurgery.Neurologia medico-chirurgica · 2025Article
- Article
- Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study.BMC neurology · 2022Observational
- Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review.Journal of cellular physiology · 2022Review
- Intracranial hemorrhage associated with direct oral anticoagulant after clipping for an unruptured cerebral aneurysm: A report of two cases.Surgical neurology international · 2022Article
- Unruptured cerebral aneurysms in elderly patients: key challenges and management.Annals of medicine · 2021Review
- Management of unruptured incidentally found intracranial saccular aneurysms.Neurosurgical review · 2021Review
- Small vs. Large Unruptured Cerebral Aneurysm: Concerns With the Age of Patient.Frontiers in neurology · 2021Article
- Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.Translational stroke research · 2020Article
- Influence of Age-Related Complications on Clinical Outcome in Patients With Small Ruptured Cerebral Aneurysms.Frontiers in neurology · 2020Article
- Characteristics of Cerebral Aneurysms in Japan.Neurologia medico-chirurgica · 2019Article
- Safety and Feasibility of Neuroendovascular Therapy for Elderly Patients: Analysis of Japanese Registry of Neuroendovascular Therapy 3.Neurologia medico-chirurgica · 2019Article
- The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms.Molecular biology reports · 2018Article
- The application of the unruptured intracranial aneurysm treatment score: a retrospective, single-center study.Neurosurgical review · 2018Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Tomohito HishikawaFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. t-hishi@md.okayama-u.ac.jp.
Isao DateFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Koji TokunagaFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Shinjiro TominariFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Kazuhiko NozakiFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Yoshiaki ShiokawaFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Kiyohiro HoukinFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Yuichi MurayamaFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Toshihiro IshibashiFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Hiroyuki TakaoFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Toshikazu KimuraFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Takeo NakayamaFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Akio MoritaFrom the Department of Neurological Surgery (T.H., I.D., K.T.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Health Informatics (S.T., T.N.), Kyoto University School of Public Health, Kyoto; Department of Neurosurgery (K.N.), Shiga University of Medical Science, Shiga; Department of Neurosurgery (Y.S.), Kyorin University School of Medicine, Tokyo; Department of Neurosurgery (K.H.), Hokkaido University Graduate School of Medicine, Sapporo; Division of Endovascular Neurosurgery (Y.M., T.I., H.T.), Department of Neurosurgery, The Jikei University School of Medicine, Tokyo; Department of Neurosurgery (T.K.), NTT Medical Center Tokyo; and UCAS Coordinating Office (A.M.), University of Tokyo, Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
For UCAS Japan and UCAS II Investigators
Jikei University School of Medicine · JPOkayama University · JPNTT Medical Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to identify risk factors for rupture of unruptured cerebral aneurysms (UCAs) in elderly Japanese patients aged 70 years or older.
methodsThe participants included all patients 70 years of age or older in 3 prospective studies in Japan (the Unruptured Cerebral Aneurysm Study of Japan [UCAS Japan], UCAS II, and the prospective study at the Jikei University School of Medicine). A total of 1,896 patients aged 70 years or older with 2,227 UCAs were investigated. The median and mean follow-up periods were 990 and 802.7 days, respectively.
resultsThe mean aneurysm size was 6.2 ± 3.9 mm. Sixty-eight patients (3.6%) experienced subarachnoid hemorrhage during the follow-up period. Multivariable analysis per patient revealed that in patients aged 80 years or older (hazard ratio [HR], 2.02; 95% confidence interval [CI], 1.16-3.49, p = 0.012), aneurysms 7 mm or larger (HR, 3.08; 95% CI, 1.35-7.03, p = 0.007 for 7-9 mm; HR, 7.82; 95% CI, 3.60-16.98, p < 0.001 for 10-24 mm; and HR, 43.31; 95% CI, 12.55-149.42, p < 0.001 for ≥25 mm) and internal carotid-posterior communicating artery aneurysms (HR, 2.45; 95% CI, 1.23-4.88, p = 0.011) were independent predictors for UCA rupture in elderly patients.
conclusionsIn our pooled analysis of prospective cohorts in Japan, patient age and aneurysm size and location were significant risk factors for UCA rupture in elderly patients.
Indexed as
AgedAged, 80 and overAge FactorsAneurysm, RupturedFemaleHumansIntracranial AneurysmJapanMaleProspective StudiesRisk Factors
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