ArticleAnnals of surgical oncology2016
The Effects of Surgery Type and Chemotherapy on Early-Stage Breast Cancer Patients' Quality of Life Over 2-Year Follow-up.
Article in Annals of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Randomized controlled trial of a breast cancer Survivor Stories intervention for African American women.Social science & medicine (1982) · 2021Trial
- Trial
- Effects of trimodal prehabilitation on quality of life and negative emotions in patients with advanced triple-negative breast cancer.Frontiers in oncology · 2026Article
- Patient factors and modifications to intended chemotherapy for women with Stages I-IIIA breast cancer.International journal of cancer · 2025Article
- Factors Associated with Poor Quality of Life in Breast Cancer Survivors: A 3-Year Follow-Up Study.Cancers · 2023Article
- Review
- Article
- Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent.Scientific reports · 2021Article
- Congruence and trajectories of device-measured and self-reported physical activity during therapy for early breast cancer.Breast cancer research and treatment · 2021Article
- A Meta-Regression Analysis of Utility Weights for Breast Cancer: The Power of Patients' Experience.International journal of environmental research and public health · 2020Article
- Pre-diagnostic allostatic load and health-related quality of life in a cohort of Black breast cancer survivors.Breast cancer research and treatment · 2020Article
- Evaluation of Long-Term Satisfaction with Breast Surgery in Patients Treated for Ductal Carcinoma In Situ: A Population-Based Longitudinal Cohort Study.Annals of surgical oncology · 2020Article
- Quality of Life Among Breast Cancer Patients Attending Hawassa University Comprehensive Specialized Hospital Cancer Treatment Center.Breast cancer (Dove Medical Press) · 2020Article
- Expectations of breast-conserving therapy: a qualitative study.Journal of patient-reported outcomes · 2019Article
- Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis.International journal of environmental research and public health · 2019Article
- Optimal designs in three-level cluster randomized trials with a binary outcome.Statistics in medicine · 2019Article
- Relative efficiency of unequal versus equal cluster sizes in cluster randomized trials using generalized estimating equation models.Biometrical journal. Biometrische Zeitschrift · 2018Article
- Accelerated partial breast irradiation compared with whole breast radiation therapy: a breast cancer cohort study measuring change in radiation side-effects severity and quality of life.Breast cancer research and treatment · 2017Article
- Optimal design of longitudinal data analysis using generalized estimating equation models.Biometrical journal. Biometrische Zeitschrift · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundWe examined the effects of surgery type and adjuvant chemotherapy on change in early-stage breast cancer patients' quality of life (QOL) over time.
methodsA cohort of 549 patients (33.5% ductal carcinoma in situ, 66.5% stages I/IIA) were interviewed a mean 6.1 weeks (Time1), and 6.2 (Time2), 12.3 (Time3), and 24.4 (Time4) months following definitive breast-conserving surgery (BCS) or mastectomy. QOL was measured using the total Functional Assessment of Cancer Therapy-Breast (FACT-B). Adjusting for demographic, psychosocial, and clinical variables, multiple linear regression models estimated the associations between QOL and each of surgery type, chemotherapy, and their 2-way interaction at each interview. Adjusted generalized estimating equation (GEE) models tested Time1-Time4 change in QOL.
resultsAt Time2, chemotherapy (P < .001) and BCS (P < .001) were independently associated with worse QOL in adjusted linear regression, and the adverse effect of chemotherapy was prominent among patients who received BCS compared with those who received mastectomy (P interaction = .031). In the GEE model, QOL significantly improved over time among patients who received BCS (P trend = .047), mastectomy (P trend = .024), and chemotherapy (P trend < .001), but not among patients who did not receive chemotherapy (P trend = .720). All patients completed adjuvant chemotherapy and radiation by Time3. Regardless of surgery type, patients receiving chemotherapy reported lower QOL following surgery, and QOL improved after completion of adjuvant treatment.
conclusionsChemotherapy had a short-term negative impact on QOL after definitive surgical treatment regardless of surgery type. QOL rebounded after completion of adjuvant treatment.
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